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Study on Metabolism and Excretion of Cartelolo in Human Urine using GC/MS
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2002, v.15 no.5, pp.482-487
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(2002). Study on Metabolism and Excretion of Cartelolo in Human Urine using GC/MS. Analytical Science and Technology, 15(5), 482-487.
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Abstract
International Olympic Committee (IOC) prohibits the use of carteolol which is one of <TEX>${\beta}$</TEX>-blockers. To prove whether carteolol product was taken or not, the analytical method in urine using GC/MS was established, and metabolism and excretion study were evaluated. As compared with acid hydrolysis, enzyme hydrolysis method was more efficiency. Coefficients of variation for intra-assay precision was around 10%. Error was less than 5% except the concentration of <TEX>$0.05{\mu}g/m{\ell}$</TEX>. Recovery was 78.5% at <TEX>$2{\mu}g/m{\ell}$</TEX>. Free carteolol, conjugated carteolol, and small amount of p-OH carteolol were found in dosed human urine samples. The conjugated form was being 59.4% of the total carteolol in human urine. The amount of carteolol renal excreted for 72 h after oral dose of 10 mg of carteolol was 49% of the administred dose.
- keywords
- carteolol, metabolite, doping, GC/MS
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