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- E-ISSN 2288-8985
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- P-ISSN1225-0163
- E-ISSN2288-8985
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Potentiometric Characteristics of Acidic Drug Selective Membrane Electrodes using Di-2-pyridyl ketone
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2003, v.16 no.4, pp.320-324
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(2003). Potentiometric Characteristics of Acidic Drug Selective Membrane Electrodes using Di-2-pyridyl ketone. Analytical Science and Technology, 16(4), 320-324.
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Abstract
Acidic drug selective electrodes based on metal(II)-di-2-pyridyl ketone-acidic drugs ternary complex as electroactive material were prepared. The metal ions, <TEX>$Fe^{2+}$</TEX>, <TEX>$Co^{2+}$</TEX>, <TEX>$Ni^{2+}$</TEX>, <TEX>$Cu^{2+}$</TEX> were used. Nitrophenyl ether series were used as plasticizers. The electrodes exhibit a fast stable and linear response for <TEX>$5{\times}10^{-5}{\sim}10^{-3}mol/L$</TEX> mefenamic acid (MA) in borate buffer solution (pH 8.9) and ibuprofen(Ib) in phosphate buffer solution (pH 7.0). The recovery test for mefenamic acid and ibuprofen using standard addition method were 99.0% and 98.4% with relative standard deviation of 2.4% and 2.6% respectively.
- keywords
- di-2-pyridyl ketone, mefenamic acid, ibuprofen
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