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- E-ISSN 2288-8985
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A study of the metabolites for 7-keto-DHEA-acetate in human urine
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2004, v.17 no.4, pp.337-346
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(2004). A study of the metabolites for 7-keto-DHEA-acetate in human urine. Analytical Science and Technology, 17(4), 337-346.
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Abstract
7-keto-dehydroepiandrosterone-acetate (7-keto-DHEA-acetate) is an anabolic steroids, and we studied basically to the metabolites of it after human dosing. We tested the matrix effect from human urine to detect the 7-keto-DHEA-acetate. And LC/ESI/MS and GC/MSD was used to detect the metabolites in dosed urine. We found the some unknown compound from dosed urine (M1, M2, M3, M4 and M5), and from these results, we supposed that these compounds have the more than 3 hydroxyl and/or ketone group. Metabolite M1 was supposed that molecular weight is 302 and 3-,17- diketone and 7-hydroxyl compound(7-OH-androstendione). Metabolite M2 was supposed that the molecular weight was same to M1 and 7-,17- diketone and 3-hydroxyl compound(7-keto-DHEA).
- keywords
- 7-keto-dehydroepiandrosterone-acetate, metabolites, human dosed urine, metabolite M1, metabolite M2, LC/ESI/MS, GC/MS
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