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Separation of racemin enantiomer carvedilol and its metabolites using capillary electrophoresis
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2006, v.19 no.4, pp.275-279
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(2006). Separation of racemin enantiomer carvedilol and its metabolites using capillary electrophoresis. Analytical Science and Technology, 19(4), 275-279.
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Abstract
A capillary electrophoresis method for the separation of carvedilol and its metabolites enantiomers using cyclodextrins as the chiral selectors was developed. The effect of several types of cyclodextrins, concentration and capillary temperature for enantiomer resolution were investigated. Best results were obtained by 15 mM carboxymethyl-<TEX>${\beta}$</TEX>-cyclodextrin in the run buffer. Also the effect of capillary temperature on efficiency was assessed. The optimized method was applied for separation of chiral carvedilol and its three metabolites.
- keywords
- carvedilol, metabolite, enantiomer, capillary electrophoresis, separation
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