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- E-ISSN 2288-8985
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Determination of lercanidipine in human plasma by LC-MS/MS
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2008, v.21 no.1, pp.34-40
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(2008). Determination of lercanidipine in human plasma by LC-MS/MS. Analytical Science and Technology, 21(1), 34-40.
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Abstract
LC-MS/MS를 이용하여 신속하고 정확한 혈장 중 레르카니디핀의 분석법을 개발하고 이 분석법 에 대한 검증을 수행하였다. 혈장에 내부표준물질로 사용한 암로디핀을 첨가한 후 아세토니트릴로 단백 질을 침전시키고, 그 상층액을 취하여 건조시킨 후 50 % 아세토니트릴로 재용해하여 LC-MS/MS로 분석 하였다. MS/MS의 MRM (multiple reaction monitoring) 방법을 이용하여 혈장 중 레르카니디핀을 어떠한 분석의 방해물 없이 선택적으로 검출할 수 있었다. 레르카니디핀의 표준 검량선은 0.05-20 ng/mL의 농 도 범위에서 우수한 직선성(r = 0.9994)을 보였으며, 일내, 일간 재현성은 변동계수 11.7% 이하, 정확성 은 94.4-114.8%로 레르카니디핀의 약물동력학적 연구에 적용되기에 충분한 감도와 특이성, 직선성, 정밀 성 및 정확성을 가지고 있음을 확인하였다.
- keywords
- lercanidipine, LC-MS/MS, pharmacokinetic study
Reference
1
1. C. Venkata and S. Ram, Am. J. Cardiol., 89(2), 214-215 (2002).
2
2. L. G. Herbette, M. Vecchiarelli, A. Sartani and A. Leonardi, Blood Press Suppl., 2, 10-17(1998).
3
3. K. J. McClellan and B. Jarvis B, Drugs, 60(5), 1123-1140(2000).
4
4. M. Epstein, Heart Dis., 3(6), 398-407(2001).
5
5. L. M. Bang, T. M. Chapman and K. L. Goa, Drugs.63(22), 2449-2472(2003).
6
6. P. A. Meredith, Expert Opin. Investig. Drugs, 8(7),1043-1062(1999).
7
7. V. Barrios, C. Escobar, Á. Navarrp, L. Barrios, J.Navarro-Cid and A. Calderón, Int. J. Clin. Pract. 60(11),1364-1370(2006).
8
8. A. Cherubini, F. Fabris, E. Ferrari, D. Cucinotta, I. R.Antonelli and U. Senin, Arch. Gerontol. Geriatr., 37(3),203-212(2003).
9
9. S. Omboni and A. Zanchetti, J. Hypertens., 16(12 Pt1), 1831-1838(1998).
10
10. A. Corsini, M. Bonfatti, P. Quarato, M. R. Accomazzo,M. Raiteri, A. Sartani, R. Testa, S. Nicosia, R.Paoletti and R. Fumagalli, J. Cardiovasc. Pharmacol.,28(5), 687-694(1996).
11
11. S. Bellosta, F. Bernini, Curr. Atheroscler. Rep., 2(1),76-81(2000).
12
12. L. A. De Giorgio, F. Orlandini, P. Malasoma and A.Zappa, Curr. Ther. Res., 60(10), 511-520(1999).
13
13. A. B. Baranda, C. A. Mueller, R. M. Alonso, R. M.Jiménez and W. Weinmann, Ther. Drug Monit., 27(1),44-52(2005).
14
14. A. B. Baranda, R. M. Alonso, R. M. Jiménez and W.Weinmann, Forensic Sci. Int., 156(1), 23-34(2006).
15
15. I. I. Salem, J. Idrees, J. I. Al Tamimi and P. Farina, J.Chromatogr. B, 803(2), 201-207(2004).
16
16. M. Kalovidouris, S. Michalea, N. Robola, M. Koutsopoulou and I. Panderi1, Rapid Commun. Mass Spectrom.,20(19), 2939-2946(2006).
17
17. V. A. P. Jabor, E. B. Coelho, D. R. Ifa, P. S. Bonato, N.A. G. dos Santos and V. L. Lanchote, J. Chromatogr. B,796(2), 429-437(2003).
18
18. V. A. P. Jabor, E. B. Coelho and V. L Lanchote, J.Chromatogr. B, 813(1-2), 343-346(2004).
19
19. J. Gibbons, J. Pugh, G. Dimopoulos-Italiano and R. Pike, Rapid Commun. Mass Spectrom., 20(11), 1715-1723(2006).
20
20. T. Yasuda, M. Tanaka and K. Iba, J. Mass Spectrom.31(8), 879-884(1996).
21
21. M. Barchielli, E.Dolfini, P. Farina, B. Leoni, G. Targa,V. Vinaccia and A. Tajana, J. Cardiovasc. Pharmacol., 29(Suppl. 2), S1-S15(1997).
22
22. Martindale, The complete drug reference, 32nd Eds., p.897(1999).
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