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- E-ISSN 2288-8985
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- E-ISSN2288-8985
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Development of an analytical method of organochlorine pesticides in human bloods using head space solid phase microextraction coupled with gas chromatography mass spectrometry
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2008, v.21 no.4, pp.259-271
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(2008). Development of an analytical method of organochlorine pesticides in human bloods using head space solid phase microextraction coupled with gas chromatography mass spectrometry. Analytical Science and Technology, 21(4), 259-271.
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Abstract
혈액 내에 축적되어 있는 유기염소계 농약을 분석하기 위한 방법으로 기존에는 액체-액체 추출 법과 고체상 추출법을 많이 사용하였으나 정제 및 많은 양의 시료 처리에 한계가 있다. 이를 극복하기 위한 방법으로 시료양이 적으며 간편한 고체상미량추출법을 사용하여 혈액 중 18종의 유기염소계 농약 의 최적 추출법을 연구하였다. 흡착조건(fiber type, 흡착시간, 흡착온도, 염석효과)과 탈착조건(탈착시간, 탈착온도) 등 최적의 추출을 위해 여러 가지의 실험조건 등을 검토한 결과, fiber는 polyacrylate 85 μm, 흡착시간은 50분, 흡착온도는 280oC, 염석효과는 NaCl 0.1 g, 탈착시간은 5분, 탈착온도는 280oC에서 최 적임을 확인하였다. 정확도, 정밀도 및 검출한계에 대한 타당성을 최적 실험조건에서 조사한 결과, 검출 한계는 0.05~0.20 ng/mL, 정밀도는 5.59~13.39%, 정확도는 -0.5%~24.5%의 범위인 것으로 확인되었다.
- keywords
- organochlorine pesticides, blood, GC/MS, SPME
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