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- E-ISSN 2288-8985
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The study of relationship between the concentrations of Bisphenol A and DEHP in human plasma and precocious puberty
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2008, v.21 no.5, pp.375-382
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(2008). The study of relationship between the concentrations of Bisphenol A and DEHP in human plasma and precocious puberty. Analytical Science and Technology, 21(5), 375-382.
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Abstract
Bisphenol A (BPA)와 di-2-ethyhexyl phthalate (DEHP)는 내분비계 장애 물질로써, 분해되지 않고 인체의 지방 및 조직에 농축되며 인체 내에 독성을 가지고 있어 상당한 문제점을 안고 있는 물질이다. 본 연구에서는 GC/MSD를 이용하여 성조숙증 환아와 정상 대조군의 혈장 내 BPA와 DEHP의 농도 분 포도를 비교 분석하여 그 상관성을 조사하였다. BPA의 경우, 성조숙증 환아가 정상 대조군에 비해 낮은 혈중 농도 분포도를 보였고, DEHP는 성조숙증 환아에서 대조군에 비해 높은 혈중 농도 분포도를 보였 다. 우리나라 성조숙증 환아의 경우에 대한 이 두 물질의 혈중 농도 분포도를 비교 검토해 볼 때, BPA 는 성조숙증에 연관성이 낮거나 또는 없으며 DEHP는 성조숙증에 어느 정도 연관이 있으며 혈중농도 분 포도는 성조숙증 환아의 경우가 대조군 보다 45%정도 높게 나타났다.
- keywords
- Bisphenol A, DEHP, precocious puberty, GC/MSD
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