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- E-ISSN 2288-8985
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- E-ISSN2288-8985
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The analysis of pharmaceuticals in drinking water by HPLC/ESI-MS/MS
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2010, v.23 no.5, pp.457-464
https://doi.org/10.5806/AST.2010.23.5.457
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(2010). The analysis of pharmaceuticals in drinking water by HPLC/ESI-MS/MS. Analytical Science and Technology, 23(5), 457-464, https://doi.org/10.5806/AST.2010.23.5.457
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Abstract
The analytical method of four pharmaceuticals (virginiamycin, erythromycin, tylosin and cimetidine) in drinking water was developed. Effective simultaneous sample clean-up and extraction by solid-phase extraction (SPE)using HLB cartridge prior to LC/ESI-MS/MS analysis were performed. A linear correlation observed in the calibration curves for drinking water in the range of 0.01~2.0 ng/mL showed above r2=0.995. Absolute recovery was in the range of 64.7~118.1% (except cimetidine (37.7~48.1%)). Limit of detection (LOD) and limit of quantitation (LOQ)in spiked drinking water matrix were in the range of 1.6~74.8 pg/mL and 5.5~249.7 pg/mL, respectively. The established method can be used to determine low pg/mL levels of pharmaceuticals in the drinking water.
- keywords
- macrolides, cimetidine, drinking water, LC/ESI-MS/MS
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