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- E-ISSN 2288-8985
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Measurement of optical purity for commercial naproxen by chiral HPLC
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2011, v.24 no.5, pp.360-367
https://doi.org/10.5806/AST.2011.24.5.360
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(2011). Measurement of optical purity for commercial naproxen by chiral HPLC. Analytical Science and Technology, 24(5), 360-367, https://doi.org/10.5806/AST.2011.24.5.360
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Abstract
Optical purities of 10 commercialized naproxens prepared from eight Korean drug companies were examined by an optimized chiral HPLC condition. The Chiralcel OD-H column and ChiralHyun-LE(S)-1 column were used as chiral stationary phases and the mixed eluent of hexane/isopropanol/acetic acid as 100:2.85:0.1was used as a mobile phase for effective enantioseparation. Optical purity values of most samples were higher than 97 percents, only one of them was about 95 percents. The average relative standard deviation of them appeared very small (0.034%).
- keywords
- chiral chromatography, optical purity, commerical naproxen
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