- P-ISSN 1225-0163
- E-ISSN 2288-8985
- Log In/Sign Up
- P-ISSN1225-0163
- E-ISSN2288-8985
- SCOPUS, ESCI, KCI
Article Detail
Home > Article Detail
Measurement of optical purity for commercial naproxen by chiral HPLC
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2011, v.24 no.5, pp.360-367
https://doi.org/10.5806/AST.2011.24.5.360
&
(2011). Measurement of optical purity for commercial naproxen by chiral HPLC. Analytical Science and Technology, 24(5), 360-367, https://doi.org/10.5806/AST.2011.24.5.360
- Downloaded
- Viewed
Abstract
Optical purities of 10 commercialized naproxens prepared from eight Korean drug companies were examined by an optimized chiral HPLC condition. The Chiralcel OD-H column and ChiralHyun-LE(S)-1 column were used as chiral stationary phases and the mixed eluent of hexane/isopropanol/acetic acid as 100:2.85:0.1was used as a mobile phase for effective enantioseparation. Optical purity values of most samples were higher than 97 percents, only one of them was about 95 percents. The average relative standard deviation of them appeared very small (0.034%).
- keywords
- chiral chromatography, optical purity, commerical naproxen
Reference
1
1. R. Bhushan and J. Martens, Biomed. Chromatogr. 12, 309-316 (1998).
2
2. A. Medvedovici, P. Sandra, L. Toribio and F. David, J. Chromatogr. A 785, 159-171 (1997).
3
3. S. C. Stinson, Chemical and Engineering News, Sep. 28, 46 (1992).
4
4. Ravi, B. and Jrgen, M., Biomedical Chromatography, 12, 309 (1998).
5
5. Willie, L. H. and Terrence, E. R., Anal Chem., 57, 237(1985).
6
6. Sándor Görög and Bulcsu Herényi, J. Phar. and Biomed. Anal., 8, 837-842 (1990).
7
7. T. Miwa, T. Miyakawa, M. Kayano and Y. Miyake, J. Chromatogr., 408, 316 (1987).
8
8. Y. Abea, S. Fukuia, Y. Koshijia, M. Kobayashia, T. Shojia, S. Sugataa, H. Nishizawaa, H. Suzukib and K. Iwatab, Biochimica et Biophysica Acta(BBA) - Protein Structure and Molecular Enzymology, 1433, 188-197(1999).
9
9. H. Nishi, K. Ishibuchi, K. Nakamura, H. Nakai and T. Sato, J. Pharmaceutical and Biomedical Anal., 13, 1483-1492 (1995).
10
10. E. Domenici, C. Bertucci, P. Salvadori, G. Félix, I. Cahagne, S. Motellier and I. W. Wainer, Chromatographia 29, 170 (1990).
11
11. T. Miwaa, T. Miyakawaa and Y. Miyakeb, J. Chromatogr. A, 457, 227-233 (1988).
12
12. E. Yashima, H. Fukaya and Y. Okamoto, J. Chromatogr. A, 677, 11-19 (1994).
13
13. W. H. Pirkle and C. J. Welch, J. Liq. Chromatogr., 15, 1947-1955 (1992).
14
14. D. M. Chen, F. Qiang, N. Li, S. X. Zhang and Q. Q. Zhang, Chinese J. Anal. Chem., 35, 75-78 (2007).
15
15. P. S. Bonato, Maria Perpetua F. M. Del Lama and C. Roberto, J. Chromatogr. B, 796, 413-420 (2003).
16
16. K. L. Williams and L. C. Sander, J. Chromatogr. A,785, 149-158 (1997).
17
17. S. K. Lee, M. S. Shin, J. G. Lee, K. T. Kang and Y. B. Kim, Bull. Korean Chem. Soc., 25, 1699 (2004).
18
18. J. J. Ryoo, Y. A. Song, Y. H. Jeong, M. H. Hyun, J. H. Park and W. Lee, Bull. Korean Chem. Soc., 27, 637(2006).
19
19. J. J. Ryoo, M. Jeon, K. S. Huh, J. Kim, J. G. Hwang, G. I. Mun and H. S. Oh, J. Korean Chem. Soc., 49, 283(2005).
20
20. W. D. Lee and J. J. Ryoo, J. Korean Chem. Soc., 55, 566 (2011).
Other articles from this issue
- Profiling analysis of catecholamines and polyamines in biological samples
- A study on aging characteristics of epoxy resins for conservation treatment of cultural heritage by adding UV stabilizer
- Determination of finasteride in human serum by LC-MS/MS
- Solvent-free determination of BTEX in water using repetitive membrane extraction followed by GC-MS
- Measurement of optical purity for commercial naproxen by chiral HPLC
- Relationship between noise and air pollution levels in Residential areas: comparison between roadside and non-roadside sites
- A study on relationship of concentration of phosphorus, turbidity and pH with temperature in water and soil
- Content and leaching characteristics of non-regulated hazardous substances in waste from the paint industry
- Content characteristics of persistent organic pollutants waste from paint, iron making and steel making process
- Removal of BrO_3^− from aqueous solution
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.