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- E-ISSN 2288-8985
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- E-ISSN2288-8985
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Fabrication and characterization of block copolymer (PCL/PCL-PEG) nanofibers binding with collagen by electrospun
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2014, v.27 no.5, pp.228-233
https://doi.org/10.5806/AST.2014.27.5.228
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(2014). Fabrication and characterization of block copolymer (PCL/PCL-PEG) nanofibers binding with collagen by electrospun. Analytical Science and Technology, 27(5), 228-233, https://doi.org/10.5806/AST.2014.27.5.228
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Abstract
Electrospun polymeric nanofibers have been extensively studied for biomedical materials becauseof their unique structures and relatively easy fabrication with biocompatible polymers. The amount of surfaceexposed amine groups increases as the blend ratio of block copolymer increases. Cell attachments on thenanofibers change according to the ratio of the block copolymer ((Poly(e-caprolactone, PCL), Poly(ecaprolactone)-Poly (ethylen glycol-NH2)) in the blend. We assume that the PEG and amine moiety plays asignificant role in biocompatibility of nanofiber surfaces. Collagen was used as a grafting material on thecomposite nanofibers to enhance the cell adhesion because the collagen is a major constituent of connectivetissue.
- keywords
- Block copolymer (PCL/PCL-PEG), Nanofiber, collagen, biocompatibility, cell adhesion
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