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  • 한국과학기술정보연구원(KISTI) 서울분원 대회의실(별관 3층)
  • 2024년 07월 03일(수) 13:30
 

  • P-ISSN1225-0163
  • E-ISSN2288-8985
  • SCOPUS, ESCI, KCI

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  • P-ISSN 1225-0163
  • E-ISSN 2288-8985

논문 상세

    Screening and detection of methylisothiazolinone and chloromethylisothiazolinone in cosmetics by UPLC-MS/MS

    분석과학 / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
    2020, v.33 no.3, pp.125-133
    https://doi.org/10.5806/AST.2020.33.3.125
    Ji Hyun Lee (National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
    Ji Hyun Paek (National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
    Han Na Park (National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
    Seongsoo Park (National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
    Hoil Kang (National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
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    Abstract

    Methylisothiazolinone (MIT) and chloromethylisothiazolinone (CMIT) cause allergic contact dermatitis and are banned cosmetics ingredients, except in rinse-off products. However, their presence has been detected in cosmetics. We report a UPLC–tandem MS/MS screening method for their simultaneous determination in cosmetics. To facilitate extraction from various matrices, pretreatment methods were developed for each sample type. The method was optimized through a series of assessments, including specificity, LOD, LOQ, linearity, recovery, stability, precision, and accuracy. The LODs and LOQs for MIT ranged from 0.054 and 0.163 μg mL−1 whereas those for CMIT ranged from 0.040 and 0.119 μg mL−1. The linear correlation coefficients (r2) were higher than 0.999. Relative standard deviations (RSDs) for both intra- and inter-day measurements ranged from 0.3 ~ 13.6 %. Recoveries at three different concentrations were within 87.9 ~ 118.9 %. The RSD for stability measurements of spiked samples was within 7 %. These results confirm the suitability of the developed method for the simultaneous quantitation of MIT and CMIT in cosmetics. Samples of 320 color cosmetics, including eyeshadows, solid lipsticks, liquid lipsticks, and nail polishes were analyzed using the developed method, and two of them were found to contain both MIT and CMIT and one of them was found to contain only MIT. This data and the method will aid the regulation of ingredients used in cosmetics.

    keywords
    LC-MS/MS, methylisothiazolinone, chloromethylisothiazolinone, cosmetics, screening


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