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  • P-ISSN 1225-0163
  • E-ISSN 2288-8985

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    Vol.35, No.2
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    Development and validation of an analytical method to quantify baphicacanthin A by LC-MS/MS and its application to pharmacokinetic studies in mice

    Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
    2022, v.35 no.2, pp.60-68
    https://doi.org/10.5806/AST.2022.35.2.60
    So Yeon Jeon (College of Pharmacy, Dankook University)
    San Kim (College of Pharmacy, Dankook University)
    Jin-Hyang Park (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University)
    Im-Sook Song (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University)
    Young Taek Han (College of Pharmacy, Dankook University)
    Min-Koo Choi (College of Pharmacy, Dankook University)
    So, Y. J. , San, K. , Jin-Hyang, P. , Im-Sook, S. , Young, T. H. , & Min-Koo, C. (2022). Development and validation of an analytical method to quantify baphicacanthin A by LC-MS/MS and its application to pharmacokinetic studies in mice. Analytical Science and Technology, 35(2), 60-68, https://doi.org/10.5806/AST.2022.35.2.60
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    Abstract

    In this study, we developed and validated a sensitive analytical method to quantify baphicacanthin A in mouse plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The standard calibration curves for baphicacanthin A ranged from 0.5 to 200 ng/mL and were linear, with an r2 of 0.985. The inter- and intra-day accuracy and precision and the stability fell within the acceptance criteria. Besides, we investigated the pharmacokinetics of baphicacanthin A following its intravenous (5 mg/kg) and oral administration (30 mg/kg). Intravenously injected baphicacanthin A showed biphasic elimination kinetics with high clearance and volume of distribution values. Furthermore, baphicacanthin A showed a rapid absorption but low aqueous solubility (182.51±0.20 mg/mL), resulting in low plasma concentrations and low oral bioavailability (2.49%). Thus, we successfully documented the pharmacokinetic properties of baphicacanthin A using this newly developed sensitive LC-MS/MS quantification method, which could be used in future lead optimization and biopharmaceutic studies.

    keywords
    baphicacanthin A, analytical method validation, LC-MS/MS, bioavailability


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