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An Analytical Method of Thromboxane <TEX>$B_2$</TEX> by Fast Atom Bombardment Mass Spectrometry
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
1993, v.6 no.4, pp.349-357
Jang,
S., Kim,
J., Lee,
Y., Jang,
S., &
Moon,
D.
(1993). An Analytical Method of Thromboxane <TEX>$B_2$</TEX> by Fast Atom Bombardment Mass Spectrometry. Analytical Science and Technology, 6(4), 349-357.
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Abstract
Analytical methods of thromboxane <TEX>$B_2(TXB_2)$</TEX> using various techniques of Fast Atom Bombardment mass spectrometry (FAB MS) were studied, static FAB condition was investigated to obtain linear response curve using docosanoic acid as a internal standard. For maximum sensitivity, a continuos-flow(CF-) FAB MS by selected-ion monitoring(SIM) with devised sample introduction system, has been developed to quantiate thromboxane <TEX>$B_2$</TEX> in biological sample. Instrumental parameters affecting sensitivity, reproducibility has been studied. The method has been optimized with respect to the eluent, 0.75% glycerol(in EtOH v/v) and flow rate of <TEX>$3.7{\mu}l/min.$</TEX> Under the condition, detection limits were below 10pg in SIM mode and a good linear relationship between dose and response was achieved.
- keywords
- Thromboxane <TEX>$B_2$</TEX>, static FAB MS, Continuos Flow FAB MS, TIC, SIM
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