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  • P-ISSN 1225-0163
  • E-ISSN 2288-8985

Determination of 2-Mercapto-1-methyl-imidazole in Antithyroid Drug by Differential Pulse Polarography

Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
1995, v.8 no.1, pp.17-23
Kim, Il Kwang
Chun, Hyun Ja
Lim, Soon Hwa
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Abstract

The determination method of 2-mercapto-1-methyl-imidazole(MMI) in <TEX>$5.0{\times}10^{-2}M$</TEX> lithium perchlorate solution has been investigated by the differential pulse polarography. The optimum conditions for the determination of MMI were as fellows; -0.9 volt(vs. Ag/AgCl) initial potential, 80mV pulse height, 2mV/sec scan rate, and medium mercury drop size. The calibration curve showed a good linearlity in the range of <TEX>$1.0{\times}10^{-7}M$</TEX> to <TEX>$8.0{\times}10^{-5}M$</TEX> and the detection limit was <TEX>$2.2{\times}10^{-9}M$</TEX>. This method was applicable to the determination of MMI in thyroid drugs without interference from the additives.

keywords
2-mercapto-1-methyl-imidazole, differential pulse polarography


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