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- E-ISSN 2288-8985
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- E-ISSN2288-8985
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A Study on the Analysis of Methylprednisolone Acetate and its Metabolites in Rat Urine by LC/MS
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
1995, v.8 no.2, pp.139-159
Park,
S., Pyo,
H. S., Kim,
Y. J., Park,
S. S., &
Park,
J.
(1995). A Study on the Analysis of Methylprednisolone Acetate and its Metabolites in Rat Urine by LC/MS. Analytical Science and Technology, 8(2), 139-159.
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Abstract
Positive ion mass spectra of some corticosteroids were obtained by using liquid chromatography-mass spectrometry(LC-MS). The base peak of each compound showed the protonated molecular ion [<TEX>$MH^+$</TEX>], ammonium adduct ion [<TEX>${MNH_4}^+$</TEX>] or [<TEX>$MH^+-60$</TEX>] ion according to its chemical structure and other characteristic mass ions were [<TEX>$MH^+-18$</TEX>], [<TEX>${MNH_4}^+-18$</TEX>] and so on. Several rat urinary metabolites of methylprednisolone acetate after the oral administration were detected by the thermospray LC-MS. The identified major metabolites were 20-hydroxymethylprednisolone(20-HMP), methylprednisolone(MP) and methylprednisone(11-KMP), which were supposed to be formed by deacetylation at the position of C-21, reduction at C-20, oxidation at C-11, or due to the bond cleavage between C-17 and C-20.
- keywords
- Methylprednisolone acetate, Metabolites Analysis, LC/MS, Rat urine
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