open access
메뉴ISSN : 0376-4672
오랜 동안 무치악 환자들에게 있어서 가철성 의치,보다 친숙하게 말해 ‘틀니’는 상당한 불편함과 번거로움이 없지는 않았지만, 잠자는 시간을 제외하면 늘 같이하는 인생의 동반자였고, 적어도 보철물이라는 이름을 가지고 있는 다른 종류들, 즉 의수, 의안, 의족등에 비해서는 매우 뛰어난 기능을 자랑하고 있었다.
The restorative treatment with dental implants in edentulous patients has been a well documented treatment modality proven in experimental studies and long-term clinical investigations. The aim of this paper is to introduce the implant mediated drug delivery system as a novel application of endosseous implants. The system is composed of hollow cylindric implants which has multiple microholes for drug delivery. For this purpose, the general outlines of drug delivery system and drug delivery route is discussed briefly. In addition, this paper deals with the results of experiments done up to now and the future perspective of the system.
1. Adell R, Lekholm U, Rockler B, Brånemark P-I. A 15-year study of osseointegrated implants in the treatment of the edentulous jaw. Int J Oral Surg 1981;10:387-416.
2. Laney WR. The emphasis on esthetics. Int J Oral Maxillofac Implants 2001:16:625.
3. Tiwari G, Tiwari R, Sriwastawa B, Bhati L, Pandey S, Pandey P. Bannerjee SK. Drug delviery systems: an updated review. Int J Pharm Investig 2012;2:2-11.
4. Kumar RB. “Needle free injection systems,” The Pharma Innovation 2012;1:57-72.
5. 한세광. 약물전달 시스템의 개발현황과 전망. Bioin 스페셜 Webzine 2008:3;1-16.
6. Kos M. Association of dental and peridontal status with bisphosphonate-related osteonecrosis of the jaws. A retrospective case controlled study. Arch Med Sci 2014;10:117-123.
7. Clark GT. Persistent orodental pain, atypical odontalgia, and phantom tooth pain: when are they neuropathic disorders? J Calif Dent Assoc 2006;34:599-609.
8. Toumba KJ, Al-Ibrahim NS, Curzon MEJ. A review of slow-releasing fluoride devices. Eur Arch Paediat Dent 2009:10;175-182.
9. Dodds MWJ, Chidichimo D, Haas MS. Delivery of active agents from chewing gum for improved remineralization. Adv Dent Res 2012;24:58-62
10. Goodson JM, Holborow D, Duun RL, Hogan P, Dunham S. Monolithic tetracycline-containing fibers for controlled delivery to periodontal pockets. J Periodontol 1983;54:575-579.
11. Haidar ZS, Hamdy RC, Tabrizian M. Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part B: Delivery systems for BMPs in orthopaedic and craniofacial tissue engineering Biotechnol Lett 2009;31:1825-1835
12. de Paula E, Cereda CMS, Fraceto F, de Araújo DR, Franz-Montan M, Tofoli GR, Ranali J, Volpato MC, Groppo F. Micro and nanosystems for delivering local anesthetics. Expert Opin Drug Deliv 2012;9:1505-1524.
13. Lee SK, Lee SW, Chung SC, Kim YK, Kho HS. Analysis of residual saliva and minor salivary gland secretions in patients with dry mouth. Arch Oral Biol 2002;47:637-641.
14. Patel VF, Liu F. Brown MB. Advances in oral transmucosal drug delivery. J Control Release 2011;153;106-116.
15. Hearnden V, Sankar V, Hull K, Juras DV, Greenberg M, Kerr AR, Lockhart PB, Patton LL, Porter S, Thornhill MH. New developments and opportunities in oral mucosal drug delivery for local and systemic disease. Adv Drug Deliv Rev 2012;64:16-28.
16. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004;27:1047-1053.
17. Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract 2010;87:4-14.
18. Park YS, Cho JY, Lee SJ, Hwang CI. Modified titanium implant as a gateway to the human body: the implant mediated drug delivery system. Biomed Res Int 2014;2014:801358 [Epub ahead of print]