Bone graft of alveolar bone defects using rhBMP-2

A new field in dental implantology is developing with the goal of finding new ways to improve the osteoconductivity of bone substitutes and to study new molecules able to dictate cellular differentiation and improve bone regeneration. The real future in bone regeneration seems to be in connection with the rhBMP-2s, currently obtained by synthesis using recombinant DNA. Since the first rhBMP-2 studies in humans by Boyne, There are many studies for bone regeneration at oral and maxillofacial area. The rhBMP-2 is widely used at sinus augmentation, alveolar bone defect, and socket preservation.

keywords: BMP, alveolar bone, guided bone regeneration

참고문헌

1. Atwood DA. Reduction of residual ridges: a major oral disease entity. J Prothet Dent 1971; 26:266-279

2. Atwood DA, Coy WA. Clinical, cephalometric and densitometric study of reduction of residual ridges. J Prothet Dent 1971; 26:280-295

3. Tallgren A. The continuing reduction of residual alveolar ridges in complete denture wearers. A mixed longitudinal study covering 25 years. J Prosthet Dent 1972; 27:120-132

4. Pietrokovski J, Sorin S, Hirschfeld Z. The residual ridge in partially edentulous patients. J Prosthet Dent 1976; 36:150-157

5. Misch CE. Available bone influences prosthodontic treatment. Dent Today 1988;Feb:44-75

6. Misch CE. Bone classifications, training keys to implant success. Dent Today 1989;May:39-44

7. Takagi K, Urist MR. The role of bone marrow in bone morphogenetic protein-induced repair of massive diaphyseal defects. Clin Orthop 1982; 171:224-231

8. Urist MR. Bone: Formation by autoinduction. Science 1965 Nov 12; 150(3698):893-899

9. Urist MR. A morphogenetic matrix for differentiation of bone tissue. Calcific Tissue Res 1970:Suppl:98-101.

10.

10. Boyne PJ, Nakamura A, Shabahang S. Evaluation of the long term effect of function on rhrhBMP-2-2 regenerated hemimandibulectomy defects. Br J Oral Maxillofac Surg 1999; 37:344-352

11.

11. Kuklo TR, Bridwell KH, Cillo YA. Is there a clinically detectable response to repeat use of rhrhBMP-2-2 in the spine? Proceeding of the NASS 22nd Annual Meeting. Spine J 2007; 7:IS-163S

12.

12. McKay WF, Peckham SM, Badura JM. A comprehensive clinical review of rhrhBMP-2-2(INFUSE Bone Graft). Int Orthop 2007; 31(6):729-734

13.

13. Urist MR, Mikulsky A, Lutz A. Solubilized and insolubilized bone morphogenetic protein. Proc Natl Acad Sci USA 1979; 76(4):1828-1832

14.

14. Toriumi DM, Kotler HS, Luxenberg DP. Mandibular reconstruction with a recombinant bone-inducing factor. Functional, histologic, and biomechanical evalution. Arch Otolaryngol Head Neck Surg 1991; 117(10):1101-1112

15.

15. Boyne PJ. The restoration of resected mandibles in children without the use of bone grafts. J Head and Neck Surg 1983; 6(2):626-631

16.

16. Wozney J. The bone morphogenetic protein family and osteogenesis. Mol Repord Dev 1992; 32(2):160-167

17.

17. Katagiri K, Yamaguchi A, Komaki M, et al. Bone morphogenetic protein-2 converts the differntiation pathway of C2C12 myoblasts into the osteoblast lineage. J Cell Biol 1994; 127:1755-1766

18.

18. Boyne PJ, Salina S, Nakamura A. Bone regenation using rhrhBMP-2-2 induction in hemimandibulectomy type defect of elderly subhuman primates. Cell Tissue Bank 2006; 7:1-10

19.

19. William K. Tom, Martin Chin, Theodore Ng. Distraction of rhBMP-2-2-generated Mandible:How stable is the engineered bone in response to subsequent surgeries? J Oral Maxillofac Surg 2008; 66:1499-1505

20.

20. Alan S. Herford, Phillip J. Boyne. Reconstruction of mandibular continuity defects with bone morphogenetic protein-2(rhBMP-2). J Oral Maxillofac Surg 2008; 66:616-624

21.

21. Herford AS, Boyne PJ, Williams RP. Clinical applications of rhBMP-2 in maxillofacial surgery. J Calif Dent Assoc 2007; 35:335-341

22.

22. Alan S. Herford. rhBMP-2 as an option for reconstructing mandibular continuity defects. J Oral Maxillofac Surg 2009; 67:2679-2684

23.

23. M. Geiger, R.H. Li, W. Freiss. Collagen sponges foe bone regeneration with rhBMP-2. Advanced Drug Delivery Review 2003; 55:1613-1629

24.

24. Zellin G, Linde A. Importance of delivery systems for growthstimulatory factors in combination with osteopromotive membranes. An experimental study using rhBMP-2 in rat mandibular defects. J Biomed Mater Res 1997; 35:181-190

25.

25. Boyne PJ, Marx RE, Nevins M, et al. A feasibility study evaluating rhBMP-2/absorbable collagen sponge for maxillary sinus floor augmentation. Int J Periodont Rest Dent 1997; 17:11-25

26.

26. Triplett GR, Nevins M, Marx RE, et al. Pivotal, Randomized, Parallel Evaluation of Recombinant Human Bone Morphogenetic Protein-2/Absorbable Collagen Sponge and Autogenous Bone Graft for Maxillary Sinus Floor Augmentation. J Oral Maxillofac Surg 2009; 66:1947-1970

27.

27. Gutwald R, Harerstroh J, Stricker A, et al:Influence of rhBMP-2 on bone formation and osseointegration in different implant systems after sinus-floor elevation. : An in vivo study on sheep. J Cranio maxillo facial surg 2010; 28:571-579

28.

28. Carter TG, Barr PS, Tolas A. Off-Label Use of Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2) for Reconstruction of Mandibular BoneDefects in Humans. J Oral Maxillofac Surg 2008; 66:1417-1425

29.

29. Herford AS, Boyne PJ, Williams RP. Bone Morphogenetic Protein-Induced Repair of the Premaxillary Cleft. J Oral Maxillofac Surg 2007; 65:2136-2141

30.

30. Boyne PJ, Lilly LC, Marx RE, et al. De novo bone induction by recombinant human bone morphogenetic protein-2 (rhBMP-2) in maxillary sinus floor augmentation. J Oral Maxillofac Surg 2005; 63:1693-1707

31.

31. Ulf ME, Wikesj? Rachel G Sorensen, John M Wozney. Augmentation of Alveolar Bone and Dental Implant Osseointegration: Clinical Implications of Studies with rhBMP-2. J Bone Joint Surg Am 2001; 83:S136-S145 2001

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53권 1호

골형성유도단백질(rhBMP-2)을 이용한 치조골 결손부의 골이식술

Bone graft of alveolar bone defects using rhBMP-2

Abstract

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