open access
메뉴
open access
메뉴
ISSN : 0376-4672
BMPs are multi-functional growth factors which are members of the transforming growth factor-beta super family and their ability is that plays a pivotal roll in inducing bone. About 18 BMP family members have been identified and characterized. Among of them, BMP-2 and BMP-7 have significant importance in bone development. In this case reports, patients of maxillary sinus graft were received who visited LivingWell Dental Hospital. We focused on the results of the surgical intervention. We suggest that new strategy of treatment used to rhBMP-2 and -TCP scaffold for patients of sinus graft. The purpose of this paper is to give a brief overview of BMPs and to critically review the clinical data currently available on rhBMP-2 and synthetic bone scaffold.
1. Boyne PJ, James RA. Grafting of the maxillary sinus floor with autogenous marrow and bone. J Oral Surg 1980; 38:613-6.
2. Tatum H Jr. Maxillary and sinus implant reconstructions. Dent Clinics of North America 1986; 30:207-29.
3. Summers RB. The osteotome technique: part 3-less invasive methods of elevating the sinus floor. Compendium 1994; 15:698,
4. Jensen OT, Shulman LB, Block MS, et al. Report of the Sinus Consensus Conference of 1996. Int J Oral Maxillofac Implants 1998; 13 Suppl:11-45.
5. Kahnberg KE, Ekestubbe A, Gro ¨ndahl K, Nilsson P, Hirsch JM. Sinus lifting procedure. I. One-stage surgery with bone transplant and implants. Clin Oral Implants Res 2001; 12:479-87.
6. del Fabbro M, Testori T, Francetti L, Weinstein R. Systematic review of survival rates for implants placed in the grafted maxillary sinus. Int J Periodontics Restorative Dent 2004; 24:565-77.
7. Wallace SS, Froum SJ. Effect of maxillary sinus augmentation on the survival of endosseous dental implants. A systematic review. Ann Periodontol 2003; 8:328-343.
8. Peleg M, Garg AK, Mazor Z. Predictability of simultaneous implant placement in the severely atrophic posterior maxilla: A 9-year longitudinal experience study of 2132 implants placed into 731human sinus grafts. Int J Oral Maxillofac Implants 2006; 21:94-102.
9. Winter AA, Pollack AS, Odrich RB. Placement of implants in the severely atrophic posterior maxilla using localized management of the sinus floor: a preliminary study. Int J Oral Maxillofac Implants 2002; 17:687-95.
10. Yeong-Wook Kim, Jang-Yeol Lee, Hyoun-Chull Kim, et al. Retrospective study of trans-crestal approach to maxillary sinus floor elevation and simultaneous implant placement. J Korean Academy Implant Dentistry 2010; 29(1):1-9
11. Urist MR. Bone formation by autoinduction. Science 1965; 150:893-9.
12. Asahina I, Sampath TK, Hauschka PV. Human osteogenic protein-1 induces chondroblastic, osteoblastic, and/or adipocytic differentiation of clonal murine target cells. Exp Cell Res 1996; 222:38-47.
13. Woo BH, Fink BF, Page R, Schrier JA, Jo YW, Jiang G, DeLuca M, Vasconez HC, DeLuca PP. Enhancement of bone growth by sustained delivery of recombinant human bone morphogenetic protein-2 in a polymeric matrix. Pharm Res2001; 18:1747-753.
14. La WG, Kang SW, Yang HS, et al. The efficacy of bone morphogenetic protein-2 depends on its mode of delivery. Artif Organs 2010; 34:1150-3.
15. Yamamoto M, Takahashi Y, Tabata Y. Enhanced bone regeneration at a segmental bone defect by controlled release of bone morphogenetic protein-2 from a biodegradable hydrogel. Tissue Eng 2006; 12:1305-11.
16. Visser R, Arrabal PM, Becerra J, Rinas U, Cifuentes M. The effect of an rhBMP-2absorbable collagen sponge-targeted system on bone formation in vivo. Biomaterials 2009; 30:2032-7.
17. Takahashi Y, Yamamoto M, Tabata Y. Enhanced osteoinduction by controlled release of bone morphogenetic protein-2 from biodegradable sponge composed of gelatin and betatricalcium phosphate. Biomaterials 2005; 26:4856-65.
18. Patel VV, Zhao L,Wong P, et al. Controlling bone morphogenetic protein diffusion and bone morphogenetic proteinstimulated bone growth using fibrin glue. Spine 2007; 31:1201-6.14.
19. Whitesides L M. Radwan A, Sharawy M. Sinus floor augmentation using a composite graft of bone morphogenic protein-2 and allogenic cancellous bone(PUROS); Case report J Oral Implantol. 2006; 32(5):259-64
20. Nevins M, Kirker-Head C, Nevins M, et al. Bone formation in the goat maxillary sinus induced by absorbable collagen sponge implants impregnated with recombinant human bone morphogenetic protein-2. Int J Periodontics RestorativeDent. 1996; 16:8-19.
21. Hanisch O, Tatakis DN, Rohrer MD, et al. Bone formation and osseointegration stimulated by rhBMP-2 following subantral augmentation procedures in nonhuman primates. Int J Oral Maxillofac Implants.1997.; 12(6):785-92.
22. Hyoun-chull Kim, Hyo-jeong Son, Jingo Kusukawa, Bone inducing effect by recombinant human bone morphogenetic protein-2 and collagen carrier in maxillary sinus of the rabbit. Journal of the Korean Academy of Implant Dentistry 2011, 30(2)115-122
23. Boyne PJ, Marx RE, Nevins M, et al. A feasibility study evaluating rhBMP-2/ absorbable collagen sponge for maxillary sinus floor augmentation. Int J Periodontics Restorative Dent. 1997; 17:11-25.
24. Boyne PJ, Lilly LC, Marx RE, et al. De novo bone induction by recombinant human bone morphogenetic protein-2(rhBMP-2) in maxillary sinus floor augmentation. J Oral Maxillofac Surg. 2005; 63:1693-1707.
25. Triplett RG, Nevins M, Marx RE, et al. Pivotal, randomized, parallel evaluation of recombinant human bone morphogenetic protein-2/absorbable collagen sponge and autogenous bone graft for maxillary sinus floor augmentation. J Oral Maxillofac Surg. 2009; 67:1947-1960.
26. Kao DW, Kubota A, Nevins M, et al. The negative effect of combining rhBMP-2 and Bio-Oss on bone formation for maxillary sinus augmentation. Int J Periodontics Restorative Dent. 2012; 32:61-67.
27. Tachi K, Takami M, Zhao B, et al. Bone morphogenetic protein 2 enhances mouse osteoclast differentiation via increased levels of receptor activator of NF-kB ligand expression in osteoblasts. Cell Tissue Res. 2010; 342:213-1220.
28. Tazaki J, Murata M,Akazawa T et al.BMP-2release and dose-response studies in hydroxyapatite and β-tricalcium phosphate Bio-Medical Materials and Engineering 19 (2009) 141-46.
29. Schopper C. Moser D. Spassova E.et al. Bone regeneration using a naturally grownloaded with rh BMP-2 is independent of barrier-membrane effects.J Biomed Mater Res A. 2008 Jun 15; 85(4):954-63.