- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Influence of Herbal Medicine Coadministration on the INR in Stroke Patients Taking Warfarin
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2004, v.25 no.2, pp.165-172
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(2004). Influence of Herbal Medicine Coadministration on the INR in Stroke Patients Taking Warfarin. Journal of Korean Medicine, 25(2), 165-172.
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Abstract
Objectives : Warfarin is a representative anticoagulant, and it has been the preferred drug for treating thromboembolic diseases and preventing ischemic stroke. It should be administered with a delicate manner, because combined therapy with other drugs could affect the INR (International Normalized Ratio), thus bleeding tendency might occur. The interaction with herbal medicine still remains controversy. We aimed to examine the effect of herbal medicine on INR in the patients being treated with warfarin. Methods : We enrolled subjects being treated with the combined therapy with warfarin and herbal medicine from 1 October, 2002 to 20 November, 2003 at the Department of Cardiovascular & Neurologic Diseases (Stroke Center), hospital of oriental medicine, Kyung Hee Medical Center. INR was monitored per 1 to 2 weeks and the significance of change was examined by Wilcoxon signed rank test or repeated measure analysis. Results : Eighty-three subjects were included in the final analysis. As a whole, their INR was not significantly changed. There were only 9 cases in which INR changed more than 1.0: seven showed increasing tendency, and two showed decreasing tendency of INR. Among the 9 cases, only 5 were suspected to have a relation with herbal medicine. Conclusions : We suggest that there was no strong evidence that herbal medicine have influence on INR, but, there is a need to perform further evaluation on large sample to reach a concrete conclusion.
- keywords
- combined therapy, warfarin, herbal medicine, INR, combined therapy, warfarin, herbal medicine, INR
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