- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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The Anti-tumor Effect of Soonkiwhajungtang with Doxorubicin in MKN-45 Conclusion
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2004, v.25 no.2, pp.98-109
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(2004). The Anti-tumor Effect of Soonkiwhajungtang with Doxorubicin in MKN-45 Conclusion. Journal of Korean Medicine, 25(2), 98-109.
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Abstract
Objective: In order to evaluate the anti-tumor and synergic effect of Soonkiwhajungtang with doxorubicin. Methods: The inhibitory concentration(IC), IC50 and IC90 of single use of doxorubicin and Soonkiwhajungtang with their concomitant treatment against MKN-45(Human Stomach carcinoma) cell line were observed using MTT(Microculture Tetrazolium test) assay. In addition, their anti-tumor effects were also observed in the xenograft nude mice models agianst MKN-45 cell line. Results: Soonkiwhajungtang has only minimal direct anti-tumor effect against Colon-26 cell line but it reduced general depressed signs induced by implantation of the tumor cell lines and increased the total WBC and lymphocyte numbers. Conclusion: It is considered or expected that Soonkiwhajungtang extract is reducing the critical toxicity of doxorubicin and has favorable synergic anti-tumor effect when administered conconitently with doxorubicin.
- keywords
- Soonkiwhajungtang, doxorubicin, anti-tumor effect, MKN-45, Soonkiwhajungtang, doxorubicin, anti-tumor effect, MKN-45
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