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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

The Anti-tumor Effect of Bojungikkeehapdaechilkitang with Doxorubicin in Colon-26

Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2004, v.25 no.2, pp.9-21


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Abstract

Objective: In order to evaluate the anti-tumor and synergic effect of Bojungikkeehapdaechilki-tang(BJDC) with doxorubicin. Methods: The inhibitory concentration(IC), IC50 and IC90 of single use of doxorubicin and BJDC with their concomitant treatment against Colon-26(Murine rectum carcinoma) cell line were observed using MTT(Microculture Tetrazolium test) assay. In addition, their anti-tumor effects were also observed in the xenograft nude mice models agianst Colon-26 cell line. Results: BJDC has only minimal direct anti-tumor effect against Colon-26 cell line but it reduced general depressed signs induced by implantation of the tumor cell lines and increased the total WBC and lymphocyte numbers. Conclusion: It is considered or expected that BJDC extract is reducing the critical toxicity of doxorubicin and has favorable synergic anti-tumor effect when administered conconitently with doxorubicin.

keywords
Bojungikkeehapdaechilkitang, doxorubicin, anti-tumor effect, Colon-26, Bojungikkeehapdaechilkitang, doxorubicin, anti-tumor effect, Colon-26


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