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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

Response to Bee Venom Acupuncture and Polymorphism of Interleukin 4 Receptor and Interleukin 10 in Rheumatoid Arthritis

Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2004, v.25 no.2, pp.207-219



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Abstract

Objective: we investigated to find out the relationship between single-nucleotide polymorphism(SNP) of IL4R, IL-10 and bee venom therapy efficacy in patients with RA treated with bee venom for 8 weeks. Methods: Korean RA patients(n=114) and healthy subjects(n=109) were included in this prospective study. Korean bee venom was dissolved in saline (diluted 1:3000) and administrated into acupuncture points. Bee venom therapy was applied twice a week and continued for 8 weeks. The clinical response was evaluated using various assessments before and after treatment. Disease severity was measured by determining the number of tender joints and swollen joints. Laboratory studies included ESR, CRP, and rheumatoid factor. Genotyping for IL-4R and IL-10 polymorphism was done by pyrosequencing analysis. Results: 1. In IL4R genotypes, there was significant difference between RA patients and controls group. 2. In IL4R genotypes, there was significant difference among Good, Mild and Bad responders to in RA patients, but in the frequency of alleles and carriers, there were no significant difference. 3. There was no significant difference between RA patients and controls group in IL-10 gene genotypes. 4. In IL-10 genotypes, there was no significant difference among Good, Mild and Bad responders to in RA patients. 5. There was no significant difference in the improvement of ESR, CRP and KHAQ scores after bee venom therapy in RA patients among the IL4R or IL-10 genotypes. Conclusions: In IL-4R genotypes, there was significant difference between RA patients and controls group, and among Good, Mild and Bad responders in RA patients. But, in IL-10 genotypes, there was no significant difference between RA patients and controls group and among Good, Mild and Bad responders in RA patients. .

keywords
Single-nucleotide polymorphism (SNP), IL4R (interleukin 4 receptor), IL-10 (interleukin 10), Rheumatoid Arthritis, Single-nucleotide polymorphism (SNP), IL4R (interleukin 4 receptor), IL-10 (interleukin 10), Rheumatoid Arthritis


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