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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

The Effects of Astragali Radix on bleomycin-induced lung fibrosis

Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2004, v.25 no.2, pp.41-50





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Abstract

Background & Objectives : Many acute and chronic lung disorders with variable degrees of pulmonary inflammation and fibrosis are colletively referred to as interstitial lung diseases. Idiopathic pulmonary fibrosis(IPF) is one of several idiopathic interstitial pneumonias with the pathogenesis unclear. Astragali Radix is known to inhibit the Th2 immune response. The effects of Astragali Radix on bleomycin-induced lung fibrosis was evaluated. Material and Methods : Astragali Radix extract was daily given to the normal rats, control(bleomycin) and treated(bleomycin and Astragali Radix extract, 24.0 mg/10g body weight) rats for 14 days. 14 days after, we observed the change of total leukocyte count and percentage, IFN-gamma and IL-4 in BALF(Bronchoalveolar lavage fluid), and of Semiquantitative histological index(SHI). Results : Compared to control rats, Astragali Radix decreased total leukocyte count(p<0.05), lymphocyte(p<0.05), neutrophil(no significance) percentage, SHI(p<0.05), IFN-gamma and IL-4(p<0.05). Otherwise, macrophage percentage was increased(p<0.01). Conclusion : This study showed that Astragali Radix reduced the change of inflammatory cells and cytokines and prevented the fibrosis of tissue in bleomycin-induced lung fibrosis rats.

keywords
IPF(Idiopathic Pulmonary fibrosis), Astragali Radix, bleomycin, IPF(Idiopathic Pulmonary fibrosis), Astragali Radix, bleomycin


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