- P-ISSN 1010-0695
- E-ISSN 2288-3339
- Apply for Authority
- P-ISSN1010-0695
- E-ISSN2288-3339
Article Detail
Home > Article Detail
Protective Effects of Palmul-tang on hypoxia-induced apoptosis in H9c2 cardiomyoblast cells
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2004, v.25 no.2, pp.67-76
&
(2004). Protective Effects of Palmul-tang on hypoxia-induced apoptosis in H9c2 cardiomyoblast cells. Journal of Korean Medicine, 25(2), 67-76.
- Downloaded
- Viewed
Abstract
Objectives : This study was designed to investigate the protective mechanisms of Palmul-tang on hypoxia-induced cytotoxicity in H9c2 cardiomyoblast cells. Methods : In this study, we used H9c2 cells. Cells were treated with hypoxia in the absence and presence of 1000μg/ml Palmul-tang for 24hrs. Cells were treated with various conentrations of Palmul-tang for 24hrs. Cell viability was measured by MTT assay. Hypoxia, markedly decreased the viability of H9c2 cells, which was characterized with apparent apoptotic features such as chromatin condensation as well as fragmentation of genomic DNA and nuclei. Results : Palmul-tang significantly reduced hypoxia-induced cell death and apoptotic characteristics. Also, Palmul-tang prevented the mitochondrial dysfunction including the disruption of mitochondrial membrane permeability transition (MPT) and an increase in expression of apoptogenic Bcl-2 proteins in hypoxia-H9c2 cells. Conclusions : This study suggests that the protective effects of Palmul-tang against hypoxic damages may be mediated by the modulation of Bcl-2, Bax expression.
- keywords
- Palmul-tang, cardiomyoblast cells, hypoxia-induced apoptosis, Palmul-tang, cardiomyoblast cells, hypoxia-induced apoptosis
Reference
1
沙圖穆蘇, (1995) 瑞竹堂經驗方: 欽定四庫全書(卷十四). , 大星文化社
2
Zweier JL, (1988) Measurement of superoxide-derived free radicals in the reperfused heart Evidence for a free radical mechanism of reperfusion injury,
3
Singh N, , (1995) Oxidative stress and heart failure,
4
Gao Z,, (2001) Protective effects of flavonoids in the roots of Scutellaria baicalensis Georgi against hydrogen peroxide-induced oxidative stress in SH-SY5Y cells,
5
姜政秀, (1995) 기아회복시 대사기질, 호르몬, 혈액성분변화에 미치는 四君子湯, 四物湯 및 八物湯의 효과, 대전대학교대학원
6
吳旼錫, (1996) 八物湯 및 B 가 運動負荷로 惹起된 筋肉疲勞와 肝代謝酵素에 미치는 實驗的 硏究, 대전대학교대학원
7
李哲浣, (1988) 四君子湯, 四物湯 및 八物湯이 근육피로회복에 미치는 실험적 연구, 경희대학교대학원
8
(1987) 少陰人 八物君子湯과 升陽益氣湯이 Hydrocortisone Acetate로 誘發된 陽虛證에 미치는 實驗的 硏究, 경희대학교대학원
9
河智容 외, (1995) 八物湯이 抗癌 및 免疫調節作用에 미치는 影響,
10
田炳薰, (1997) 八物湯加味方이 마우스의 貪食細胞機能 및 免疫反應에 미치는 影響, 원광대학교대학원
11
鄭雨哲, (2002) 배양심근세포의 산화적 손상에 대한 四君子湯의 방어효과, 원광대학교대학원
12
趙權一, (2002) 배양심근세포의 산화적 손상에 대한 四物湯의 방어효과, 원광대학교대학원
13
(1992) 六君子湯이 高脂血症에 미치는 影響, 원광대학교대학원
14
(1988) 四物湯 및 四君子湯이 endotoxin으로 유발된 血栓症에 미치는 影響, 경희대학교대학원
15
南昌圭, (1998) 四物湯이 血管內皮細胞에 미치는 影響, 원광대학교대학원
16
己, (1995) 校註婦人良方: 欽定四庫全書(卷三十一. 氏醫案). , 大星文化社
17
김창민 외, (1998) 完譯中藥大辭典, 도서출판 정담
18
申善澔, (1998) 生脈散이 實驗動物의 心筋細胞에 미치는 影響, 원광대학교대학원
19
孫昶翼, (2000) 丹參飮 煎湯液이 培養 心筋細胞에 미치는 影響, 원광대학교대학원
20
黃普淵, (2002) 심근세포의 산화적 손상에 대한 五味子湯의 효과 및 작용기전 연구, 원광대학교대학원
21
成恩慶, (2002) 通靈散 抽出物이 培養 心筋細胞에 미치는 影響, 원광대학교대학원
22
MacLellan WR, (1997) Death by design Programmed cell death in cardiovascular biology and disease,
23
Apostolova MD,, (1999) Metallothionein and apoptosis during differentiation of myoblasts to myotubes protection against free radical toxicity,
24
Chen QM,, (2000) Hydrogen peroxide dose dependent induction of cell death or hypertrophy in cardiomyocytes,
25
Raff MC, (1993) Programed cell death and the control of cell survival,
26
Wu ML, (1996) Mechanism of hydrogen peroxide and hydroxyl free radical-induced intracellular acidification in cultured rat cardiac myoblasts,
27
Sowter HM, (2003) Predominant Role of Hypoxia-Inducible Transcription Factor -1alpha versus Hif-2alpha in Regulation of the Transcriptional Response to Hypoxia,
28
Calvert JW, (2003) Effect of hyperbaric oxygen on apoptosis in neonatal hypoxia-ischemia rat model,
29
Naora, H.,, (1996) Constituvely enhanced nbl expression is associated with the induction of inter-nucleosomal DNA cleavage by actinomycin D,
30
Knowlton AA, (2003) HSP60, Bax, and Cardiac Apoptosis,
31
Allen RT, (1998) Mechanism controlling cellular suicide: role of Bcl-2 and caspases,
32
Kroemer G, (1998) The mitochondrial death/life regulator in apoptosis and necrosis,
33
Trauth BC, (1989) Monoclonal antibody-mediated tumor regression by induction of apoptosis,
34
Herr, I., , (1997) Activation of CD95 signaling by ceramide mediates cancer therapy-induced apoptosis,
35
Ekhterae D, , (1999) ARC inhibits cytochrome c release from mitochondria and protects against hypoxia-induced apoptosis in heart-derived H9c2 cells,
- Downloaded
- Viewed
- 0KCI Citations
- 0WOS Citations
Other articles from this issue
- Studies on the antioxidation and antimicrobial effect of Smilacis Glabrae Rhizoma
- The Anti-tumor Effect of Bojungikkeehapdaechilkitang with Doxorubicin in Colon-26
- Effects of CPs(combined preparation of Radix Salvia Mltiorrhiza, Radix Notoginseng, and Borneolum) on Hyperlipidemia
- The Apoptosis Inducing Effect of Radix Aconiti Extract in HepG2 Human Hepatoma Cells
- The Effects of Astragali Radix on bleomycin-induced lung fibrosis
- Effects of Bojeongjeongcheon-Tang on Cytokines and Immunoglobulin E in B Cells
- Protective Effects of Palmul-tang on hypoxia-induced apoptosis in H9c2 cardiomyoblast cells
- A Correlation Research of Appetite and Dining Habit According to Sasang Constitution
- Effects of Taeyeumjowee-tang on Loss in Body weight, Plasma Lipids and UCP I Revelation of Fated White Rats
- The Anti-tumor Effect of Soonkiwhajungtang with Doxorubicin in MKN-45 Conclusion
- The Clinical Effects of Gamichuongsangboha-tang (Jiaweiqingshangbuxia-tang)extract in Asthmatic Patients Based on Severity
- A paper on the present condition of Cheong-Gang(晴崗) medical chart -Means of acquisition, filing condition and research value
- Effects of Sohaphyang-won on the Gene Expression in a Hypoxic Model of Cultured Rat Cortical Cells
- Effect on Alzheimer's Disease by Sesim-tang in CT105-overexpressed SK-N-SH cell lines
- Sasang Typology from a Personality Perspective
- Influence of Herbal Medicine Coadministration on the INR in Stroke Patients Taking Warfarin
- Protective Effects of Jihwangeumja on Oxidative Stress-induced Injury of Human Umblical Vein Endothelial Cells
- Effects of Gwibitang on Glutamate-induced Death in Rat Neonatal Astrocytes
- Effect of JiaoTeng-Yuan(交藤圓) on Oxidation Stress Caused by D-galactose in Sprague-Dawley Rats
- Response to Bee Venom Acupuncture and Polymorphism of Interleukin 4 Receptor and Interleukin 10 in Rheumatoid Arthritis
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.