- P-ISSN 1010-0695
- E-ISSN 2288-3339
- Apply for Authority
- P-ISSN1010-0695
- E-ISSN2288-3339
Article Detail
Home > Article Detail
Effects of Gwibitang on Glutamate-induced Death in Rat Neonatal Astrocytes
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2004, v.25 no.2, pp.184-193
&
(2004). Effects of Gwibitang on Glutamate-induced Death in Rat Neonatal Astrocytes. Journal of Korean Medicine, 25(2), 184-193.
- Downloaded
- Viewed
Abstract
Objectives: This study was designed to investigate effects of Gwibitang on the glutamate-induced toxicity of primary rat neonatal astrocytes. Methods and Results: Gwibitang significantly recovered the glutamate-induced apoptosis and inhibited the generation of H2O2 in astrocytes. In addition, both Gwibitang and antioxidants such as GSH protected the glutamate-induced cytotoxicity in astrocytes, indicating that Gwibitang possibly had a antioxidative effect. Moreover, Gwibitang also inhibited the glutamate-induced degradation of Bcl-2 protein and poly(ADP)-ribose polymerase (PARP) in astrocytes. Conclusions: we suggest that Gwibitang has protective effects on glutamate-induced cytotoxicity via an antioxidative mechanism.
- keywords
- Gwibitang, Glutamate, Astrocytes, Gwibitang, Glutamate, Astrocytes
Reference
1
嚴用和, (1995) 定四庫全書.醫家類., 대성문화사
2
黃度淵, (2000) 證脈 方藥合編. , 南山堂
3
尹用甲, (2002) 東醫方劑와 處方解說, 의성당
4
Choi DW, (1987;7) Glutamate neurotoxicity in cortical cell culture,
5
Cho Y, (1990;55) Uptake of glutamate and cystein in C6 glioma cells and in cultured astrocytes,
6
Kato S, (1992;48) A mechanism for glutamate toxicity in the C6 glioma cells involving inhibition of cystine uptake leading to glutathione depletion,
7
Derick H , (1997) Protection against glutamate-induced cytotoxicity in C6 glial cells by thiols antioxidants,
8
Gotz M, (1990;29) a role in the pathogenesis of Parkinson's disease,
9
Fischer G, (1985;159) Cultured astrocytes form a syncytium after maturation,
10
Mikoshiba K, (1993;197) Cerebellar astrocytes specifically support the survival of Purkinje cells in culture,
11
Ju C, (2000) Synergistic depletion of astrocytic glutathione by glucose deprivation and peroxynitrite correlation with mitochondrial dysfunction and subsequent cell death,
12
Kim YM, (1997) Nitric Oxide Inhibits Apoptosis by Preventing increase in Caspace-3 like Activity via Distinct Mechanism,
13
鄭遇悅,, (1998) 東醫臨床病理學, 永林社
14
Peter L, (1999) Ischemic Cell Death in Brain Neurons,
15
고재영, (1998) 신경계 질환에서의 apoptosis,
16
金都煥, (2000) Nitric Oxide에 의해 유발된 C6 glial 세포독성에 대한 四物湯의 방어효과,
17
李英九, (2000) 右歸丸이 Zinc에 의한 神經膠細胞의 고사에 미치는 영향, 원광대학교 대학원
18
S Desagher, (2000) Mitochondria as the central control point of apoptosis?Trends.,
19
I Budihardjo,, (1999) Biochemical pathways of caspase activation during apoptosis?Annu. Rev.,
20
Martin SJ, (1995) Protease activation during apoptosis Death by a thousand cuts,
21
Henkart PA, (1996) ICE family proteases: mediators of all apoptotic cell death,
22
Lazebnik YA, (1994;371) Cleavage of poly polymerase by a proteinase with properties like ICE,
23
Enari M,, (1998) A caspase-activated DNase that degrades DNA during apoptosis and its inhibitor ICAD.,,
- Downloaded
- Viewed
- 0KCI Citations
- 0WOS Citations
Other articles from this issue
- Studies on the antioxidation and antimicrobial effect of Smilacis Glabrae Rhizoma
- The Anti-tumor Effect of Bojungikkeehapdaechilkitang with Doxorubicin in Colon-26
- Effects of CPs(combined preparation of Radix Salvia Mltiorrhiza, Radix Notoginseng, and Borneolum) on Hyperlipidemia
- The Apoptosis Inducing Effect of Radix Aconiti Extract in HepG2 Human Hepatoma Cells
- The Effects of Astragali Radix on bleomycin-induced lung fibrosis
- Effects of Bojeongjeongcheon-Tang on Cytokines and Immunoglobulin E in B Cells
- Protective Effects of Palmul-tang on hypoxia-induced apoptosis in H9c2 cardiomyoblast cells
- A Correlation Research of Appetite and Dining Habit According to Sasang Constitution
- Effects of Taeyeumjowee-tang on Loss in Body weight, Plasma Lipids and UCP I Revelation of Fated White Rats
- The Anti-tumor Effect of Soonkiwhajungtang with Doxorubicin in MKN-45 Conclusion
- The Clinical Effects of Gamichuongsangboha-tang (Jiaweiqingshangbuxia-tang)extract in Asthmatic Patients Based on Severity
- A paper on the present condition of Cheong-Gang(晴崗) medical chart -Means of acquisition, filing condition and research value
- Effects of Sohaphyang-won on the Gene Expression in a Hypoxic Model of Cultured Rat Cortical Cells
- Effect on Alzheimer's Disease by Sesim-tang in CT105-overexpressed SK-N-SH cell lines
- Sasang Typology from a Personality Perspective
- Influence of Herbal Medicine Coadministration on the INR in Stroke Patients Taking Warfarin
- Protective Effects of Jihwangeumja on Oxidative Stress-induced Injury of Human Umblical Vein Endothelial Cells
- Effects of Gwibitang on Glutamate-induced Death in Rat Neonatal Astrocytes
- Effect of JiaoTeng-Yuan(交藤圓) on Oxidation Stress Caused by D-galactose in Sprague-Dawley Rats
- Response to Bee Venom Acupuncture and Polymorphism of Interleukin 4 Receptor and Interleukin 10 in Rheumatoid Arthritis
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.