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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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혈관내피세포의 산화적 손상에 대한 地黃飮子의 방어기전 연구

Protective Effects of Jihwangeumja on Oxidative Stress-induced Injury of Human Umblical Vein Endothelial Cells

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2004, v.25 no.2, pp.173-183
정용준 (원광대학교)
장재호 (원광대학교)
이대용 (원광대학교)
이민구 (원광대학교)
전인철 (원광대학교)
정대영 (원광대학교)
이인 (부산대학교)
신선호 (원광대학교)
문병순 (원광대학교)
정용준, 장재호, 이대용, 이민구, 전인철, 정대영, 이인, 신선호, & 문병순. (2004). 혈관내피세포의 산화적 손상에 대한 地黃飮子의 방어기전 연구. 대한한의학회지, 25(2), 173-183.
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Abstract

Objectives: Oxidative stress can induce negative responses such as growth inhibition or cell death by necrosis or apoptosis due to the intensity of the oxidative stress, as well as positive responses such as cellular proliferation or activation. Methods and Results: We analyzed the influence of oxidative stress and agents that modify its effect in human umbilical vein endothelial cell(HUVEC). Oxidative stress was induced by H2O2. With induced oxidative stress the results obtained indicate that it has a harmful effect over cell function and viability, and that this effect is dose and time dependent. When oxidative stress increased, Jihwangeumja reduced cell damage and had protective functions. H2O2 induced the apoptosis of HUVEC through the acivation of intrinsic caspases pathway as well as mitochondrial dysfunction. A significant increase in cell survival was observed in culture cells with oxidative stress when they were treated with Jihwangeumja. Conclusions: These results suggest that Jihwangeumja may be potentially useful to treat HUVEC against oxidative damages mediated by modulation of caspase protease and mitochondrial dysfunction.

keywords
Jihwangeumja, Oxidative Stress-induced Injury, Human Umblical Vein Endothelial Cells, Jihwangeumja, Oxidative Stress-induced Injury, Human Umblical Vein Endothelial Cells


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