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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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歸脾湯이 Glutamate에 의한 성상세포의 손상에 미치는 영향

Effects of Gwibitang on Glutamate-induced Death in Rat Neonatal Astrocytes

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2004, v.25 no.2, pp.184-193
전희준 (원광대학교)
박세욱 (원광대학교)
이인 (부산대학교)
문병순 (원광대학교)
전희준, 박세욱, 이인, & 문병순. (2004). 歸脾湯이 Glutamate에 의한 성상세포의 손상에 미치는 영향. 대한한의학회지, 25(2), 184-193.
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Abstract

Objectives: This study was designed to investigate effects of Gwibitang on the glutamate-induced toxicity of primary rat neonatal astrocytes. Methods and Results: Gwibitang significantly recovered the glutamate-induced apoptosis and inhibited the generation of H2O2 in astrocytes. In addition, both Gwibitang and antioxidants such as GSH protected the glutamate-induced cytotoxicity in astrocytes, indicating that Gwibitang possibly had a antioxidative effect. Moreover, Gwibitang also inhibited the glutamate-induced degradation of Bcl-2 protein and poly(ADP)-ribose polymerase (PARP) in astrocytes. Conclusions: we suggest that Gwibitang has protective effects on glutamate-induced cytotoxicity via an antioxidative mechanism.

keywords
Gwibitang, Glutamate, Astrocytes, Gwibitang, Glutamate, Astrocytes


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