논문 상세

Home > 논문 상세
  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

황기가 C57BL/6J 생쥐의 Bleomycin유발 肺纖維化에 미치는 影響

The Effects of Astragali Radix on bleomycin-induced lung fibrosis

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2004, v.25 no.2, pp.41-50
이경희 (경희대학교)
정희재 (경희대학교)
정승기 (경희대학교)
윤유식 (경희대학교)
이형구 (경희대학교)
  • 다운로드 수
  • 조회수

Abstract

Background & Objectives : Many acute and chronic lung disorders with variable degrees of pulmonary inflammation and fibrosis are colletively referred to as interstitial lung diseases. Idiopathic pulmonary fibrosis(IPF) is one of several idiopathic interstitial pneumonias with the pathogenesis unclear. Astragali Radix is known to inhibit the Th2 immune response. The effects of Astragali Radix on bleomycin-induced lung fibrosis was evaluated. Material and Methods : Astragali Radix extract was daily given to the normal rats, control(bleomycin) and treated(bleomycin and Astragali Radix extract, 24.0 mg/10g body weight) rats for 14 days. 14 days after, we observed the change of total leukocyte count and percentage, IFN-gamma and IL-4 in BALF(Bronchoalveolar lavage fluid), and of Semiquantitative histological index(SHI). Results : Compared to control rats, Astragali Radix decreased total leukocyte count(p<0.05), lymphocyte(p<0.05), neutrophil(no significance) percentage, SHI(p<0.05), IFN-gamma and IL-4(p<0.05). Otherwise, macrophage percentage was increased(p<0.01). Conclusion : This study showed that Astragali Radix reduced the change of inflammatory cells and cytokines and prevented the fibrosis of tissue in bleomycin-induced lung fibrosis rats.

keywords
IPF(Idiopathic Pulmonary fibrosis), Astragali Radix, bleomycin, IPF(Idiopathic Pulmonary fibrosis), Astragali Radix, bleomycin


참고문헌

1

American Thoracic Society, (2000) Idiopathic pulmonary fibrosis : diagnosis and treatment. International consensus statement. American Thoracic Society(ATS) and the European Respiratory Society(ERS). ,

2

Copper JA Jr,, (1988;39) Mechanisms of drug-induced pulmonary disease,

3

張天嵩, (1999) 補氣通肺湯治療特發性肺纖維化12例., 浙江中醫雜誌

4

張偉 , (1995) 中西醫結合呼吸病診療學. , 南海出版公司

5

陳永輝, (1998) 常見呼吸系疾病中西醫結合診斷與治療, 中國醫藥科技出版社

6

黃 및 當歸의 면역증강효과에 관한 연구,

7

이경민, (2003) 황기약침액의 NO DPPH 消法 및 IL-4 억제효과,

8

Wei H, (2003) Traditional Chinese medicine Astragalus reverses predominance of Th2 cytokines and their up-stream transcript factors in lung cancer patients,

9

Kremer S,, (1999) Effect of immunomodulators on bleomycin-induced lung injury,

10

Laxer U,, (1999) The effect of enoxaparin on bleomycin-induced lung injury in mice,

11

Berkman N, (1997) Bleomycin-induced lung injury is enhanced by interferon-α,

12

Lossos IS,, (1998) Peribronchial lymphocyte activation in bleomycin-induced lung injury,

13

강 희, (2001) 황기에 의한 Helper T 세포의 생존 및 활성 증가,

14

송정섭, (2003) 특발성 간질성폐렴의 진단적 접근방법 결핵 및 호흡기질환,

15

김동순, (2003) 특발성폐섬유증(IPF)의 치료.결핵 및 호흡기질환 ,

16

Selman M,, (2001) prevailing and evolving hypotheses about its pathogenesis and implications for therapy,

17

어수택, (2003Feb) 폐섬유화증의 병인 및 병태생리,

18

Venkatesan N,, (2002oct) Proteoglycan expression in bleomycin lung fibroblasts role of transforming growth factor-beta(1) and interferon-gamma,

19

Huang M, (2002apr) IL-7 inhibits fibroblast TGF-beta production and signaling in pulmonary fibrosis,

20

Mosmann TR, , (1996) The expanding universe of T-cell subsets; Th1 Th2 and more,

21

Keane MP, (2001) IL-12 attenuates bleomycin-induced pulmonary fibrosis,

22

Blease K,, (2001) Therapeutic effect of IL-13 immunoneutralization during chronic experimental fungal asthma,

23

Strieter RM, (1989;162) Monocyte chemotactic protein gene expression by cytokine-treated human fibroblasts and endothelial cells,

24

Li D, Different cytokine profiles in cryptogenic fibrosing alveolitis and fibrosing alveolitis associated with systemic sclerosis a quantitative study of open lung biopsies,

25

Wallace WA, (1995) A type 2 (Th2-like) pattern of immune response predominates in the pulmonary interstitium of patients with cryptogenic fibrosing alveolitis (CFA).,

26

Walker C, (1994oct;150) Activated T cells and cytokines in bronchoalveolar lavages from patients with various lung diseases associated with eosinophilia,

27

Jaffe HA, (1999) Selective inhibition of collagen gene expression in fibroblasts by an interferon-gamma transgene,

28

Keane MP,, (1999nov) IFN-gamma-inducible protein-10 attenuates bleomycin-induced pulmonary fibrosis via inhibition of angiogenesis,

29

Sempowski GD,, (1996) Interleukin-4 and interferon-gamma discordantly regulate collagen biosynthesis by functionally distinct lung fibroblast subsets,

30

Lossos IS, (2002) Cyclosporin A upmodulates bleomycin-induced pulmonary fibrosis in BALB/c mice,

31

정순희, (1995) 백서에서 Bleomycin 투여로 인한 폐손상 및 폐섬유화에 대한 Vitamin E의 영향,

32

Gutteridge JM, (1981;99) Protection of iron-catalysed the radical damage to DNA and lipids by copper,

33

이광길, Bleomycin에 의한 폐손상의 기전에 관한 형태학적 硏究,

34

이중달, Bleomycin의 기관내 투여로 유발된 폐장의 간질성 섬유증식증의 實驗적 硏究,

  • 다운로드 수
  • 조회수
  • 0KCI 피인용수
  • 0WOS 피인용수

권호 내 다른 논문

추천 논문

상단으로 이동

대한한의학회지