- P-ISSN 1225-0163
- E-ISSN 2288-8985
- P-ISSN1225-0163
- E-ISSN2288-8985
- SCOPUS, ESCI, KCI
Article Detail
Home > Article Detail
The Determination of 5-Fluorourasil in Human Plasma by a Gas Chromatography-Mass Spectrometry
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
1998, v.11 no.1, pp.36-41
Shin,
H., Seo,
B., Oh,
Y., &
Park,
S.
(1998). The Determination of 5-Fluorourasil in Human Plasma by a Gas Chromatography-Mass Spectrometry. Analytical Science and Technology, 11(1), 36-41.
- Downloaded
- Viewed
Abstract
A gas chromatography-mass spectrometry method for the determination of 5-fluorourasil in human plasma is described. The method involves a single extraction procedure with 10 ml of isopropanol-ether(20:80) solution and pentafluoro-benzylation. Samples were injected using an automatic injector, followed by separation on a nonpolar capillary column and detection with a mass selective detector(MSD). No endogeneous compounds were found to interfere. The detection limit, based upon an assayed plasma volume of 0.5, was 3 ng/ml. The extraction yield was found to be above 80%. Plasma 5-FU concentrations were determined by this method in about 500 plasma samples from cancer patients undergoing treatment with 5-FU. This method is suitable for monitoring of 5-FU in plasma of cancer patients.
- keywords
- 5-FU, Determination, Plasma, GC-MS
- Downloaded
- Viewed
- 0KCI Citations
- 0WOS Citations
Other articles from this issue
- Development of Controlling and Analyzing Software for Portable Atomic Emission Spectrometry
- Synthesis and Characterization of 2,2'-Biimidazole
- Photocatalytic Reaction of Sensitizer, Rose Bengal and Supersensitizer, Allylthiourea
- A Study on the Photocatalytic Dimerization of Rose Bengal and Allylthiourea
- Contents of Cr and Co in Some Fisheries Caught in the West Coast
- The Determination of 5-Fluorourasil in Human Plasma by a Gas Chromatography-Mass Spectrometry
- <TEX>$({\eta}^5-C_5Me_5)_2BiCl$</TEX>, The First Organobismuth Compound with <TEX>$\pi$</TEX>-bonded Cyclopentadienyl Ring Analysized by X-ray Diffractometry
- Fundamental Investigation of Non-invasive Determination of Glucose by Near Infrared Spectrophotometry
- Comparision of Chemical Components of Ligusticum chuanzxiong HORT and Cnidium officinale MAKINO
- A Study on the Characteristic Trace Organic Pollutants in the Industrial Wastewater
- <TEX>$^{13}C$</TEX> NMR Analysis for the Characterization of Heme Electronic/Molecular Structure in Horse Myoglobin Cyanide
- Principle and Instruments of Tandem Mass Spectrometry
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.