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The Determination of 5-Fluorourasil in Human Plasma by a Gas Chromatography-Mass Spectrometry
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
1998, v.11 no.1, pp.36-41
Shin,
H., Seo,
B., Oh,
Y., &
Park,
S.
(1998). The Determination of 5-Fluorourasil in Human Plasma by a Gas Chromatography-Mass Spectrometry. Analytical Science and Technology, 11(1), 36-41.
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Abstract
A gas chromatography-mass spectrometry method for the determination of 5-fluorourasil in human plasma is described. The method involves a single extraction procedure with 10 ml of isopropanol-ether(20:80) solution and pentafluoro-benzylation. Samples were injected using an automatic injector, followed by separation on a nonpolar capillary column and detection with a mass selective detector(MSD). No endogeneous compounds were found to interfere. The detection limit, based upon an assayed plasma volume of 0.5, was 3 ng/ml. The extraction yield was found to be above 80%. Plasma 5-FU concentrations were determined by this method in about 500 plasma samples from cancer patients undergoing treatment with 5-FU. This method is suitable for monitoring of 5-FU in plasma of cancer patients.
- keywords
- 5-FU, Determination, Plasma, GC-MS
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