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- E-ISSN 2288-8985
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Fundamental Investigation of Non-invasive Determination of Glucose by Near Infrared Spectrophotometry
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
1998, v.11 no.1, pp.47-53
Kim,
H. J., Woo,
Y. A., Chang,
S. H., Cho,
C. H., Cantrell,
K., &
Piepmeier,
E.
H.
(1998). Fundamental Investigation of Non-invasive Determination of Glucose by Near Infrared Spectrophotometry. Analytical Science and Technology, 11(1), 47-53.
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Abstract
This study is to improve the diagnosis of diabetes mellitus and the self-monitoring of blood glucose in people with diabetes by providing a non-invasive method of monitoring blood glucose. A near-infrared (NIR) spectrophotometer was used to measure absorption spectra of 80 glucose samples ranges from 1 mg/dL to 200 mg/dL, and shows the standard error of prediction 1.8 mg/dL. Also, to investigate the effect of interference in blood, NaCl and sand were added in glucose and found the standard error of prediction of 2.8 mg/dL and 3.8 mg/dL, respectively. A new and more accurate calibration system for the spectrophotometer was developed from systematic study of light scattering, which cause nonlinear spectrophotometer response.
- keywords
- near infrared spectrophotometry, glucose, non invasive determination, scattering, Partial least-squares regression (PLS), multiple linear regression (MLR)
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