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Determination of Diazepam in Intact Diazepam Tablets Using Near Infrared Spectroscopy
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2002, v.15 no.3, pp.8-247
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(2002). Determination of Diazepam in Intact Diazepam Tablets Using Near Infrared Spectroscopy. Analytical Science and Technology, 15(3), 8-247.
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Abstract
rapid and simple determination of diazepam in intact diazepam tablets has been investigated using the near infrared spectroscopy(NIRS) combined with partial least squares regession . The separate calibration curves of 2 mg and 5 mg diazepam tablets were studied, as well as the linearity, concentration range and reproducibility of those calibration curves were evaluated. The correlation coefficients of calibration curves of 2 mg and 5 mg diazepam tablets are 0.9416 and 0.9159, respectively and the standard errors of calibration curves(SEC) are 0.018% and 0.032%, respectively.
- keywords
- NIR spetroscopy, partial least squares regression, diazepam, pharmaceutical analysis
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