- P-ISSN 1225-0163
- E-ISSN 2288-8985
- P-ISSN1225-0163
- E-ISSN2288-8985
- SCOPUS, ESCI, KCI
Article Detail
Home > Article Detail
Determination of Sildenafil and Its Related Substances Using High Performance Thin Layer Chromatography
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2003, v.16 no.1, pp.32-38
&
(2003). Determination of Sildenafil and Its Related Substances Using High Performance Thin Layer Chromatography. Analytical Science and Technology, 16(1), 32-38.
- Downloaded
- Viewed
Abstract
The rapid and sensitive determination method of sildenafil and its related compounds (Vardenafil, Homosildenafil, Tadanafil.) has been investigated using high performance thin layer choromatography (HPTLC). Optimizing separation conditions and simultaneous determination method of these compounds were studied. The calibration curves of those compounds at 254 nm was found to be linear in the range of <TEX>$1.0{\sim}56.5{\mu}g/mL$</TEX>, respectively. The detection limts (LOD) and quantification limits (LOQ) of these were found to be <TEX>$0.8{\sim}1.8{\mu}g/mL$</TEX> and <TEX>$1.0{\sim}2.3{\mu}g/mL$</TEX>. The coefficient of variation (C.V.) were less than 2.5%. Finally, the present method was applied to determine sildenafil and its related substances in dietary supplement.
- keywords
- Sildenafil, HPTLC, Dietary supplement
Other articles from this issue
- The Comparison of Volatile Organic Compounds (VOCs) Analysis and Tradescantia Micronucleus (Trad-MCN) Bioassay for Evaluation of Hazardous Materials in Chemical Workplace Field
- Development of Neutron Induced Prompt r-ray Spectrocscopy System Using 252 Cf
- Properties and Analytical Methods of Polychlorinated biphenyls in Environments(Ⅱ)
- Synthesis and stuctural analysis of chromium(lll) picolinate complexs
- CHEMISTRY : THE COMPARISON OF VOLATILE ORGANIC COMPOUNDS (VOCS) ANALYSIS AND TRADESCANTIA MICRONUCLEUS (TRAD-MCN) BIOASSAY FOR EVALUATION OF HAZARDOUS MATERIALS IN CHEMICAL WORKPLACE FIELD
- Determination of Sildenafil and Its Related Substances Using High Performance Thin Layer Chromatography
- Analysis of 226Ra in the Groundwater Using the Gamma-ray Spectroscopy
- CHEMISTRY : DEVELOPMENT OF NEUTRON INDUCED PROMPT Γ-RAY SPECTROSCOPY SYSTEM USING 252CF
- The Effects of Physico-chemical Properties of soils on PCBs Analysis
- CHEMISTRY : SYNTHESIS AND STRUCTURAL ANALYSIS OF CHROMIUM(3) PICOLINATE COMPLEXES
- Simultaneous Determination of 4-Nitrotoluene and Benzophenone in Ground Water and Soil by Gas Chromatography-Mass Spectroscopy
- CHEMISTRY : DETERMINATION OF SILDENAFIL AND ITS RELATED SUBSTANCES USING HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY
- ENVIROMENTAL SCIENCE : ANALYSIS OF 226RA IN THE GROUNDWATER USING THE GAMMA-RAY SPECTROSCOPY
- Gas chromatographic Analysis on the Residual of Fungicide Fenhexamid in Crops(Cucumber, Strawberry and Grape)
- A Study on the potimal HPLC condition for peptides complex analysis using mass spectrometry
- Determination of Ni, Cr, Mo in Low Alloy Steel Reference Materials by Isotope Dilution Inductively Coupled Plasma Mass Spectrometry
- ENVIROMENTAL SCIENCE : SIMULTANEOUS DETERMINATION OF 4-NITROTOLUENE AND BENZOPHENONE IN GROUND WATER AND SOIL BY GAS CHROMATOGRAPHY-MASS SPECTROSCOPY
- An evaluation of uncertainty of random effects with correlation - gravimetric preparation of standard gas-
- ENVIROMENTAL SCIENCE : GAS CHROMATOGRAPHIC ANALYSIS ON THE RESIDUAL OF FUNGICIDE FENHEXAMID IN CROPS(CUCUMBER, STRAWBERRY AND GRAPE)
- NOTE : A STUDY ON THE OPTIMAL HPLC CONDITION FOR PEPTIDES COMPLEX ANALYSIS USING MASS SPECTROMETRY
- NOTE : DETERMINATION OF NI, CR, MO IN LOW ALLOY STEEL REFERENCE MATERIALS BY ISOTOPE DILUTION INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY
- NOTE : AN EVALUATION OF UNCERTAINTY OF RANDOM EFFECTS WITH CORRELATION - GRAVIMETRIC PREPARATION OF STANDARD GAS -
- Properties and Analytical Methods of Polychlorinated biphenyls in Environments(I)
- Properties and Analytical Methods of Polychlorinated biphenyls in Environments(II)
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.