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Method Validation and Uncertainty Estimation for Toluene Measurement in Biological Fluids by HS-GC
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2004, v.17 no.6, pp.443-453
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(2004). Method Validation and Uncertainty Estimation for Toluene Measurement in Biological Fluids by HS-GC. Analytical Science and Technology, 17(6), 443-453.
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Abstract
Toluene is currently used as a major organic solvent of glues which are abused by the youngster for its hallucinogenic effect. In this study, toluene determination method using headspace gas chromatography (HS-GC) in the biological fluids like blood, urine and saliva of glue sniffers was validated and related uncertainties were estimated. LOD of 0.01 μg/mL in saliva and LOQ of 0.1 μg/mL in blood were the highest among LODs and LOQs in urine, blood and saliva. Other performance characteristics such as linearity, working range, accuracy, precision and recovery were also measured. The uncertainty at toluene concentration of 1 μg/mL was estimated to be 0.13, 0.09 and 0.17 μg/mL for blood, urine and saliva, respectively, and the uncertainty contribution from the least linear regression was dominant at the lower concentration of toluene.
- keywords
- validation, uncertainty, toluene
Reference
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(1998) The Fitness for Purpose of Analytical Methods, EURACHEM
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(2000) Quantifying Uncertainty in Analytical Meaure- ments, EURACHEM
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(1993) Guide to the Expression of Uncertainty in Measurements, ISO
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(19-262000) "측정 및 분석 결과의 불확도(I) -국제 규범(GUM)에 맞는 불확도 산출 및 표현",
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(1995) CRC handbook of Chemistry and Physics, CRC Press
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