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Determining Anti-impotence drug-like compounds in Food
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2004, v.17 no.6, pp.520-526
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(2004). Determining Anti-impotence drug-like compounds in Food. Analytical Science and Technology, 17(6), 520-526.
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Abstract
determine 6 anti-impotence drug-like compounds such as sildenafil, vardenafil, tadalafil, homosildenafil, hydroxyhomosildenafil and hongdenafil in food, simultaneously, high performance liquid chromatography was applied. In the case of solid sample, it was extracted in organic solvents after homogenizing with mortar and pestle. Whereas liquid sample was just diluted in water and then extracted in organic solvents. Maximum lengths of UV for targets have been identified on photodiode array spectra. As results, vardenafil, hongdenafil, hydroxyhomosildenafil, sildenafil, homosildenafil, and tadalafil were eluted in order using C18 column in acetonitrile containing phosphoric acid as the mobile phase. The maximum wavelength (λmax) was 216 nm for vardenafil, 233 and 282 nm for hongdenafil, 222 and 293 nm for hydroxyhomosildenafil, sildenafil and homosildenafil, and 284 nm for tadalafil. The overall recoveries were ranged from 95% to 109% and the limit of detection was about 0.04 mg/kg at signal/noise>3. Levels of targets in the selected food samples were 1.7(hongdenafil)～63(tadalafil) mg/one dose.
- keywords
- hongdenafil, hydroxyhomosildenafil, homosildenafil, food, HPLC
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