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- E-ISSN 2288-8985
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Determination of pseudoephodrine, dextromethorphan and their metabolites in human urine by gas chromatography - mass spectrometry
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2007, v.20 no.4, pp.315-322
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(2007). Determination of pseudoephodrine, dextromethorphan and their metabolites in human urine by gas chromatography - mass spectrometry. Analytical Science and Technology, 20(4), 315-322.
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Abstract
This study has been described the metabolism and excretion in a healthy male urine collected for 24 hr after oral administration of a complex (pseudoephedrine and dextromethorphan). To detect the trace amounts of parent drugs and their metabolites, acid-hydrolyzed urine was extracted and derivatized with MSTFA and MBTFA followed by gas chromatography/mass spectrometric analysis. Two parent drugs and their metabolites were tentatively identified as their derivatives based on the mass spectral interpretation and compared with previous reports. In addition, the time profile of urinary excretion rate for parent drugs and metabolites was studied. On the basis of metabolites identified and excretion rate, the metabolic pathways of both drugs are suggested.
- keywords
- Pseudoephedrine, dextromethorphan, oral administration, metabolites, urine, GC-MS
Reference
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Keith Parker, (1997) Goodman & Gilman's The Pharmacological Basis ofTherapeutics, McGraw-Hill
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Grattan, (1995) Br. J. Clin. Pharmacol,
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Chai, (1995) J. Pharm. Biomed. Anal,
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T. H. Eichcold, (2007) Pharm. Biomed. Anal,
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