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- E-ISSN 2288-8985
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- P-ISSN1225-0163
- E-ISSN2288-8985
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Development of a rapid HPLC method for the determination of penciclovir in human plasma using a monolithic column and its application to a bioequivalence study
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2007, v.20 no.4, pp.323-330
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(2007). Development of a rapid HPLC method for the determination of penciclovir in human plasma using a monolithic column and its application to a bioequivalence study. Analytical Science and Technology, 20(4), 323-330.
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Abstract
A simple and rapid HPLC method with fluorescence detection(FLD) for quantitation of penciclovir in human plasma using a monolithic column was developed and validated. Penciclovir and ganciclovir(internal standard, I.S.) were separated on a Chromolith column RP-18e (<TEX>$4.6{\times}100mm$</TEX>) with a mobile phase consisting of a mixture of (A) methanol/50 mM sodium phosphate buffer containing 200 mg/L sodium dodecyl sulfate (3/97, pH 2.5) and (B) methanol/50 mM sodium phosphate buffer containing 200 mg/L sodium dodecyl sulfate (50/50, pH 2.5) at a flow gradient of <TEX>$1.6{\sim}4.0mL/min$</TEX>. The retention times of penciclovir and internal standard were less than 4.0 min. Calibration curve was linear (<TEX>$R^2
- keywords
- Penciclovir, HPLC-Fluorescence Detection, Monolithic column, Bioequivalence study, Plasma
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