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Simultaneous determination of parabens in cosmetics by LC/MS
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2010, v.23 no.1, pp.54-59
https://doi.org/10.5806/AST.2010.23.1.054
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(2010). Simultaneous determination of parabens in cosmetics by LC/MS. Analytical Science and Technology, 23(1), 54-59, https://doi.org/10.5806/AST.2010.23.1.054
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Abstract
The simultaneous analysis of parabens in cosmetic samples was carried out by LC/MS. The cosmetic samples are directly dissolved in methanol and filterated using 0.45 μm filter. The methanol-water was used for the mobile phase of gradient conditions. An Extend C18 reverse-phase column and the selected ion monitoring (SIM) mode were applied. The analysis results of LC/MS showed good linearity with correlation coefficient of r2=0.9993 in the range of 0.05 to 10 μg/mL and detection limit of 0.01 μg/mL.
- keywords
- paraben, LC/MS
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