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- E-ISSN 2288-8985
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- P-ISSN1225-0163
- E-ISSN2288-8985
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Simultaneous analysis and occurrences of six pharmaceuticals in surface water by LC/ESI-MS/MS
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2010, v.23 no.6, pp.572-578
https://doi.org/10.5806/AST.2010.23.6.572
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(2010). Simultaneous analysis and occurrences of six pharmaceuticals in surface water by LC/ESI-MS/MS. Analytical Science and Technology, 23(6), 572-578, https://doi.org/10.5806/AST.2010.23.6.572
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Abstract
In this study, sample preparation and analytical method for the monitoring of six pharmaceuticals (cephradine, cefadroxil, penicillin G, vancomycin, iopromide, and fenbendazole) in surface water was investigated. The extraction/clean-up and concentrating of pharmaceuticals from surface water were performed by HLB (Hydrophilic-Lipophilic Balanced) cartridge. The method allows for the simultaneous determination of six pharmaceuticals by HPLC/ESI(+)-MS/MS. Recoveries of the pharmaceutical were between 71.1 to 92.6%(except fenbendazole) and the overall variability of the method was below 11.2% (RSD). The calibration curves for the pharmaceuticals from blank surface water showed good linearities (above r2 = 0.99) in the concentration range of 0.007~1.2 ng/mL. The limit of detection (LOD) and the limit of quantification (LOQ) were 7.2~128.7pg/mL and 23.8~429.1 pg/mL, respectively. The present analytical method can be useful for monitoring residual pharmaceuticals in surface water and other aquatic samples. High concentrations of iopromide and fenbendazole were detected in a few samples of surface water.
- keywords
- pharmaceuticals, surface water, chemical analysis, LC/ESI-MS/MS
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