- P-ISSN 1225-0163
- E-ISSN 2288-8985
- P-ISSN1225-0163
- E-ISSN2288-8985
- SCOPUS, ESCI, KCI
Article Detail
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Trace level analysis of Pb in plasma by inductively coupled plasma/mass spectrometry
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2012, v.25 no.3, pp.190-196
https://doi.org/10.5806/AST.2012.25.3.190
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(2012). Trace level analysis of Pb in plasma by inductively coupled plasma/mass spectrometry. Analytical Science and Technology, 25(3), 190-196, https://doi.org/10.5806/AST.2012.25.3.190
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Abstract
The human exposure of lead has usually detected the amount of lead in the whole blood, however,this method has a shortcoming to give the information on the short-term exposure to lead. In that sense, it is desirable to estimates the level of lead in plasma to draw the chronic bio-marker of lead exposure even though it is difficult to measure lead of several ng/L. An inductively coupled plasma-mass spectrometry (ICPMS)method was developed for determining lead in plasma as the chronic bio-marker of lead of workers. To minimize the contamination of lead from the environment, we constructed class 1,000 clean room and compared the amount of floating dust before and after the operation of the clean room. The limit of detection (LOD)and the limit of quantification (LOQ) of lead in fetal bovine serum were 4.3 ng/L and 12.2 ng/L by NIOSH method (statistical calculation method) and 7.0 ng/L and 22.1 ng/L by signal/noise ratio, respectively. The accuracy was in a range of 92.3-101.3%, and the precision of the assay was less than 4% in the samples spiked in the concentration of 20 ng/L and 2,000 ng/L. The method was simple, reproducible and sensitive enough to permit reliable analysis of lead to the ng/L level in plasma and/or serum. The method was also useful for the biological monitoring of chronic exposure to lead.
- keywords
- lead, plasma, inductively coupled plasma-mass spectrometry, chronic bio-marker
Reference
1
1. N.-S. Kim, J.-H. Kim, B.-K. Jang, H.-S. Kim, K.-D. Ahn and B.-K. Lee, J. Kor. Soc. Environ. Hyg., 17(1), 43-52 (2007).
2
2. KOSHA, Survey on work environment: lead, http://eip.kosha.or.kr/jsp/Main.jsp?On=OPEN, 2009.
3
3. Ministry of Environment, Lead Risk Assessment Report, Ministry of Environment, 2007.
4
4. Korea Industrial Safety Association, Safety Training sheet: Safety Measures for Lead Poisoning (KISAHealth-05), 2007.
5
5. KOSHA, Material Safety Data Sheet: Lead, http://msds.kosha.or.kr/web/kosha/msds02/Msds02SingleView.jsp, 30 Sep 2011.
6
6. ACGIH. Lead, elemental and inorganic, ACGIH, lead BEI1-15, 2001.
7
7. S. S. Choi and S. H. Lee, J. Kor. Soc. Environ. Administration, 8(4), 331-337 (2002).
8
8. K. S. Park and S. T. Kim, Anal. Sci. Tech., 10(4), 240-245 (1997).
9
9. M. Hernández-Avila, D. Smith, F. Meneses, L. H. Sanin and H. Hu, Environ. Health Perspectives, 106(8), 473-477 (1998).
10
10. G. A. K. Koyashiki, M. M. B. Paoliello, T. Matsuo, M. M. B. Oliveira, L. Mezzaroba, M. Fátima Carvalho, A. M. Sakuma, C. Turini, M. T. O. Vannuchi and C. S. D. Barbosa, Environ. Res., 110, 265-271 (2010).
11
11. A. Schütz, I. A. Bergdahl, A. Ekholm and S. Skerfving, Occup. Environ. Med., 53, 736-740 (1996).
12
12. I. A. Bergdahl, M. Vahter, S. A. Counter, A. Schütz, L. H. Buchanan, F. Ortega, G. Laurell and S. Skerfving, Environ. Res. Sec. A, 80, 25-33 (1999).
13
13. V. B. Rezende, J. H. Amaral, R. F. Gerlach, F. barbosa Jr. and J. E. Tanus-Santos, J. Trace Elements in Medicine and Biology, 24, 147-151 (2010).
14
14. M. F. Montenegro, F. Barbosa Jr, V. C. Sandrim, R. F. Gerlach and J. E. Tanus-Santos, Arch Toxicol., 80, 394-398 (2006).
15
15. R. Cornelis, B. Heinzow, R. F. M. Herber, J. Molin Christensen, O. M. Paulsen, E. Sabbioni, D. M. Templeton, Y. Thomassen, M. Vahter and O. Vesterberg, Pure & Appl. Chem., 67, 1575-1608 (1995).
16
16. C. D. Palmer, M. E. Lewis Jr., C. M. Geraghty, F. Barbosa Jr. and P. J. Parsons, Spectrochimica Acta part B, 61, 980-990 (2006).
17
17. J. A. Nunes, B. L. Batista, J. L. Rodrigues, N. M. Caldas, J. A. Neto and F. Barbosa Jr, J. Toxicol. Environ. Health Part A. 73(13-14), 878-887 (2010).
18
18. G. R. Almeida, C. F. Freitas Tavares, A. M. Souza, T. S. Sousa, C. A. R. Funayma, F. Barbosa Jr, J. E. Tnus-Santos and R. F. Gerlach, Sci. Total Environ., 408, 1551-1556 (2010).
19
19. B. L. Batista, D. Grotto, J. L. Rodrigues, V. C. Oliveira Souza and F. Barbosa Jr, Anal. Chimica Acta, 646, 23-39 (2009).
20
20. E. Bakowska, Agilent Technologies, Publication no. 5988-0533EN, 2001.
21
21. I. A. Bergdahl, A. Schütz, L. Gerhardsson, A. Jensen and S Skerfving, Scand. J. Work Environ. Health, 23, 359-363 (1997).
22
22. D. Smith, M. Hernandez-Avila, M. M. Téllez-Rojo, A. Mercado and H. Hu, Environ. Health Perspectives, 110(3), 263-268 (2002).
23
23. K. M. Cake, R. J. Bowins, C. Vaillancourt, C. L. Gordon, R. H. McNutt, R. Laporte, C. E. Webber and D. R. Chettle, American J. Indust. Medicine, 29, 440-445 (1996).
24
24. B. K. Lee, J. J. Kim, K. H. Woo and H. S. Kim, Health Care Technology Research and Development Annual Report, Department of Health and Human Services, 2002.
25
25. H.-S. Nam, K.-H. Nam, S. H. Jung, J. W. Lee, J. Y. Kang, S. K. Hong, T. S. Kim, T. S. Kang, H-J Yoon, K. H. Lee and G-S Rhee, Anal. Sci. Technol., 24(5), 345-351 (2011).
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