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    Vol.35, No.4
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    A Review: Synthesis and characterization of metals complexes with paracetamol drug

    Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
    2022, v.35 no.4, pp.143-152
    https://doi.org/10.5806/AST.2022.35.4.143
    Salam R AL-Ayash (Chemistry Department, College of Education for Pure Science Ibn-Al-Haithem, University of Baghdad)
    Taghreed H AL-Noor (Chemistry Department, College of Education for Pure Science Ibn-Al-Haithem, University of Baghdad)
    Salam, R. A. , & Taghreed, H. A. (2022). A Review: Synthesis and characterization of metals complexes with paracetamol drug. Analytical Science and Technology, 35(4), 143-152, https://doi.org/10.5806/AST.2022.35.4.143
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    Abstract

    In this review, previous studies on the synthesis and characterization of the metal Complexes with paracetamol by elemental analysis, thermal analysis, (IR, NMR and UV-Vis (spectroscopy and conductivity. In reviewing these studies, the authors found that paracetamol can be coordinated through the pair of electrons on the hydroxyl O-atom, carbonyl O-atom, and N-atom of the amide group. If the paracetamol was a monodentate ligand, it will be coordinated by one of the following atoms O-hydroxyl, O-carbonyl or N-amide. But if the paracetamol was bidentate, it is coordinated by atoms (O-carbonyl and N-amide), (O-hydroxyl and N-amide) or (O-carbonyl and O-hydroxyl). The authors also found that free paracetamol and its complexes have antimicrobial activity.

    keywords
    complex, donor atom, paracetamol, analytical and spectral studies


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