- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Effects of Armillaria mellea Extract on Macrophage and NK Cell Activity
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2004, v.25 no.4, pp.161-170
Byoung-Wook,
P.
, Jang-Woo,
S.
, Jung-Hyo,
C.
, Yeon-Weol,
L.
, Hwa-Seung,
Y.
, Nam-Heon,
L.
, Dam-Hee,
Y.
, &
Chong-Kwan,
C.
(2004). Effects of Armillaria mellea Extract on Macrophage and NK Cell Activity. Journal of Korean Medicine, 25(4), 161-170.
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Abstract
Objective: The purpose of this study was to investigate the effects of Armillaria mellea extract (AME) on immune modulation focused on anti-cancer activity.Methods To prove the effects of AME, we performed NO assay, NK cytotoxicity assay and RT-PCR of cytokine related with macrophage and NK cell activity. Results AME increased NO production produced by macrophages in part. AME also enhanced the NK cell activities in destroying target cells (YAC-1 cells). AME up-regulated gene expression of IL-1, iNOS, TNF-α in RAW 264.7 cells and IL-1, IL-2, IFN-γ, TNF-α in splenocytes, respectively. Conclusion From the above results, we assumed that AME is a potential drug for anti-cancer by activation of the macrophages and NK cells.
- keywords
- Armillaria mellea extract (AME), NK cell, macrophage, Armillaria mellea extract (AME), NK cell, macrophage
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