- P-ISSN 1010-0695
- E-ISSN 2288-3339
- Log In/Sign Up
- P-ISSN1010-0695
- E-ISSN2288-3339
Article Detail
Home > Article Detail
Effects of Armillaria mellea Extract on Macrophage and NK Cell Activity
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2004, v.25 no.4, pp.161-170
Byoung-Wook,
P.
, Jang-Woo,
S.
, Jung-Hyo,
C.
, Yeon-Weol,
L.
, Hwa-Seung,
Y.
, Nam-Heon,
L.
, Dam-Hee,
Y.
, &
Chong-Kwan,
C.
(2004). Effects of Armillaria mellea Extract on Macrophage and NK Cell Activity. Journal of Korean Medicine, 25(4), 161-170.
- Downloaded
- Viewed
Abstract
Objective: The purpose of this study was to investigate the effects of Armillaria mellea extract (AME) on immune modulation focused on anti-cancer activity.Methods To prove the effects of AME, we performed NO assay, NK cytotoxicity assay and RT-PCR of cytokine related with macrophage and NK cell activity. Results AME increased NO production produced by macrophages in part. AME also enhanced the NK cell activities in destroying target cells (YAC-1 cells). AME up-regulated gene expression of IL-1, iNOS, TNF-α in RAW 264.7 cells and IL-1, IL-2, IFN-γ, TNF-α in splenocytes, respectively. Conclusion From the above results, we assumed that AME is a potential drug for anti-cancer by activation of the macrophages and NK cells.
- keywords
- Armillaria mellea extract (AME), NK cell, macrophage, Armillaria mellea extract (AME), NK cell, macrophage
Reference
1
(1998) Immunology, Mosby International Ltd
2
(1997) Cellular and molecular immunology, U.S.A, W.B.Saunders Company
3
(1996) Nitric oxide inhibits macrophage pseudopodia formation in the activated macrophages,
4
(1982;30) Role of NK cells in the control of metastatic spread of tumor cells in mice,
5
(1983;p1157) In Progress in Immunology V Edited by Tada, Academic Press
6
(1983;131) Capacity of human large granular lymphocyte,
7
(1997) Natural killer cell-target cell interactions. ,
8
(1994;14) Immunomodulatory function of polysaccharide of Hericium erinaceus,
9
(1997) Medical immunology, Appleton & Lange
10
(2001) Recognition of tumor cells by the innate immune system Current opinion in immunology,
11
(2000) The cancer-preventive potential of Panax ginseng a review of human and experimental evidence Cancer Causes Control,
12
(1998) Inhibitory effects of ginsenoside Rh2 on tumor growth in nude mice bearing human ovarian cancer cells,
13
(1999) Effects of astragali radix extract on carcinogenesis and cytotoxicity in mice treated with a carcinogen N-butyl-N'-butanolnitrosoamine,
14
(1992;14) A potent Chinese biological response modifier in cancer immunotherapy potentiation and detoxification of anticancer dr㎍s,
15
(2001) The effects of a Chinese herb formulaanti-cancer number one (ACNO) on NK cell activity and tumor metastasis in rats. ,
16
(1994;9) Chinese medicinal herbs inhibit growth of murine renal cell carcinoma,
17
(1994;14) Immunomodulatory function of polysaccharide of Hericium erinaceus,
18
(1997) Anticarcinogenic effect and hormonal effect of Cordyceps militaris Link,
19
(1999) AIDS-associated malignancies research perspectives. Biochimica et Biophysica Acta (BBA)/Reviews on Cancer. 1999;1423:1:1-9. ,
20
(1987;78) Cancer in families with severe combined immune deficiency,
21
(1998) Angiogenesis and Tumor Metastasis,
22
(2001) Nitric oxide and the regulation of gene expression,
23
(1997) Biosynthesis and action of nitric oxide in mammalian cells,
24
(1990;76) Biology and clinical relevance of human natural killer cells,
- Downloaded
- Viewed
- 0KCI Citations
- 0WOS Citations
Other articles from this issue
- Effect of Do-In (Prunus persica L. BATSCH) Water Extract (PPE) on Concentration of Extracellular Acetylcholine in the Rat Hippocampus
- The Anti-nociceptive and Anti-inflammatory Effect of Achyranthes Japonica Nakai
- Effects of Bambusae concretio Silicea on Suppression of Collagenolysis and Bone Resorption in Mouse Calvarial Osteoblasts
- Inhibitory effects of transforming growth factor and Drynariae Rhizoma on leukocytosis associated with the chronic phase of arthritis in mice
- Study on the Relationship between Polymorphisms in Glutathione S-transferase and Ischemic Cerebrovascular Disease
- Correlation between Obesity and Lumbar Lordosis in Obese Pre-Menopausal Korean Females
- Effect of Saenggitang on Learning and Memory Ability in Mice
- Experimental Studies on the Effect of Gamibaegi-eum
- Cytotoxic effects of ethanol extracts of Saussurea lappa mediated by mitochondrial apoptotic pathway
- Effects of Panax Ginseng on the Sperm Motility and Spermatogenesis in the SD Rat
- Paeonia radix decreases intracerebral hemorrhage-induced neuronal cell death via suppression on caspase-3 expression in rats
- Inhibition of cell growth and induction of apoptosis by Euonymus alatus (Thunb.) Sieb in human leiomyomal smooth muscle cells
- Susceptibility of Oral Bacteria to Essential Oil of Artemisia capillaris Thunb
- A PILOT STUDY TO ASSESS THE EFFECT OF GAMI-JIWHANG-TANG ON COGNITIVE EFFECTS IN HEALTHY CHILDREN
- A PILOT STUDY FOR DEVELOPING AN ASSESSMENT SCALE FOR THE EFFECT OF HERBAL MEDICINE IN HEALTHY CHILDREN: OPEN-LABEL STUDY WITH GAMI-JIWHANGTANG
- Identification of Angelica Species by Pyrosequencing
- Analysis of Survival in 273 Terminally Ill Cancer Patients Treated with Traditional Oriental Therapies
- Effects of Armillaria mellea Extract on Macrophage and NK Cell Activity
- A Study on the Clinical Features of Ordinary Sleeping Patterns Based on the Sasang Constitution, Using the Logistic Regression
- Screening for Various Herb Medicines Extracts against HSV-1,2
- Novel Therapeutic Approach toward Inflammatory Diseases: Targeting Transglutaminase 2
- Effects of Palmijihwangtang (PMT) and Exercise on Glucose Metabolism in Myocardium Cell Membrane and Pancreas β-Cell of Zucker Diabetic Fatty Rats
- Study on the Relationship between Candidate Genes of Cerebral Infarction and Sasang Constitution
- A Clinical Study of Electroacupuncture on an Overactive Bladder
- A Case Report for One Case of Thyrotoxic Periodic Paralysis Patient
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.