- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Screening for Various Herb Medicines Extracts against HSV-1,2
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2004, v.25 no.4, pp.180-187
Seong-Woo,
L.
(2004). Screening for Various Herb Medicines Extracts against HSV-1,2. Journal of Korean Medicine, 25(4), 180-187.
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Abstract
In order to find antiviral compounds against Herpes simplex virus type Ⅰ(HSV-1) and Herpes simplex virus type Ⅱ(HSV-2) from herb medicines, a convenient virus-induced cytopathic effect (CPE) inhibition assay was introduced. Forty-four purchased herbal medicines, and their toxicity of infected cell and anti-viral activities were evaluated. Among them, the major part of herbal medicines showed cell stability compared with the contrast. Cytotoxic concentration (CC) of the H2O extracts of Sanpoongkosamwhan against HSV-1 and HSV-2 was 18.5, Chonyolchesuptang against HSV-1 and HSV-2 was 13.1, Whangyonhaedoktang against HSV-1 and HSV-2 was 15.3, Hyongbangpaedoksan against HSV-1 and HSV-2 was 9.3. These are high level cytotoxic concentration compared with the contrast. Therefore, we assumed that the high level cytotoxic concentration of various herbal medicines play a major role in improvement of antiviral activity at the first infective cell. But the antiviral effect was not determined for selective index (SI)=CC50/EC50. The other herbal medicines were not determined to show potent anti-HSV 1,2 activity. The antiviral activation using herbs in this thesis have unlimited objects, to select research objects that will help to show a direction for antiviral drug development that will have fewer side effects and more excellent efficiency.
- keywords
- Anti-viral effect, Herb Medicines, Screening, Herpes simplex virus type Ⅰ (HSV-1), Herpes simplex virus type Ⅱ(HSV-2), Anti-viral effect, Herb Medicines, Screening, Herpes simplex virus type Ⅰ (HSV-1), Herpes simplex virus type Ⅱ(HSV-2)
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