Article Detail

Home > Article Detail
  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

Study on the Relationship between Polymorphisms in Glutathione S-transferase and Ischemic Cerebrovascular Disease

Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2004, v.25 no.4, pp.36-42
Sang-Hyuk Han
Sae-Wook Park
Yong-Il Shin
Kwang-Ho Cho
Byung-Soon Moon
  • Downloaded
  • Viewed

Abstract

Purpose : Glutathione S-transferase polymorphism (GST) were examined in 120 cases with ischemic cerebrovascular disease (ICVD) to test the hyperthesis that GST polymorphisms confer a risk to an individual to develop ICVD. Tobacco smoking is a major cause of both cancer and vascular disease. Methods : therefore We were stratified the subjects with ICVD for smoking status, and then examined whether polymorphisms in this detoxification enzyme gene, GST, influence risk of ICVDResult : Neither GSTM1 nor GSTT1 genotypes in the ICVD group was significantly different from the control group (n=207), even in smokers. We attempted the combined analyses for GSTM1 and GSTT1 genotypes in ICVD for smoking status. No significant association observed between the combined genotypes and ICVDConclusion : Our observation do not confirm the effect of the GSTM1 and GSTT1 genotypes as a risk factor for ICVD, even in smokers.

keywords
Glutathione S-transferase polymorphism (GST), schemic cerebrovascular disease (ICVD), tobacco smoking., Glutathione S-transferase polymorphism (GST), schemic cerebrovascular disease (ICVD), tobacco smoking.


Reference

1

(1996) Genes for ischaemic stroke strategies for their detection,

2

Advances in tobacco carcinogenesis, ven Press

3

(1990) The possible involvement of somatic mutations in the development of atherosclerotic plaques Report of ICPEMC Subcommittee 7/1 Conclusions and recommendations,

4

(1993) The pathogenesis of atherosclerosis a perspective for the 1990s,

5

(1997) Molecular epidemiology of atherosclerosis,

6

(carcinogenesis1988) Arteriosclerotic plaque development is 'promoted' by polynuclear aromatic hydrocarbons,

7

(1996) 1,3 Butadiene a vapor phase component of environmental tobacco smoke, accelerates arteriosclerotic plaque. ,

8

(carcinogenesis19941821-1824) Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder,

9

Modular mutagenesis of exons 1 and 8 of a glutathione S-transferase from the mu class Mechanistic and structural consequences for chimeras of isoenzyme 3-3,

10

(1997) A novel class of glutathione transferases in a range of species from plants to humans,

11

(1997) Genotypes of glutathione transferases M1 and P1 and their significance for lung DNA adduct levels and cancer risk,

12

(1996) Glutathione S-transferase GSTT1genotypes and susceptibility to cancer studies of interactions with GSTM1 in lung oral, gastric and colorectal cancers,

13

(1999) Drug metabolism polymorphisms as modulators of cancer susceptibility,

14

(2000) Glutathione S-transferase M1 null genotype is associated with a decreased risk of myocardial infarction,

15

(1988) A simple salting out procedure for extracting DNA from human nucleated cells,

16

(1996) A multiplex PCR procedure for polymorphic analysis of GSTM1 and GSTT1 genes in population studies,

17

(1995) Ethnic differences in the prevalence of the homozygous deleted genotype of glutathione S-transferase theta,

18

(1993) a common inherited defect of the carcinogen-metabolism gene glutathione S-transferase M1 that increases susceptibility to bladder cancer,

19

(2001) Genetic polymorphisms in cytochrome P450 (CYP) 1A1, CYP1A2, CYP2E1, glutathione S-transferase (GST) M1 and GSTT1 and susceptibility to prostate cancer in the Japanese population. Cancer Lett. 2001. ,

20

(2000) Genetic susceptibility to chronic obstructive pulmonary disease in Koreans combined analysis of polymorphic genotypes for microsomal epoxide hydrolase and glutathione S-transferase M1 and T1,

21

(1993) Polymorphism of glutathione conjugation of methyl bromide ethylene oxide and dichloromethane in human blood influence on the induction of sister chromatid exchanges,

22

(1996) Simultaneous characterization of glutathione S-transferase M1 and T1polymorphisms by polymerase chain reaction in American whites and blacks,

23

(2000) genetics and role in toxicology: genetics and role in toxicology,

  • Downloaded
  • Viewed
  • 0KCI Citations
  • 0WOS Citations

Other articles from this issue

Recommanded Articles

상단으로 이동

Journal of Korean Medicine