- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Effect of Saenggitang on Learning and Memory Ability in Mice
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2004, v.25 no.4, pp.51-60
Yun-Jeong,
H.
, Gyu-Tae,
C.
, &
Jang-Hyun,
K.
(2004). Effect of Saenggitang on Learning and Memory Ability in Mice. Journal of Korean Medicine, 25(4), 51-60.
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Abstract
Objective: The effect Saenggitang (生氣湯, SGT), which has been used for amnesia, in Oriental Medicine, on memory and learning ability, was investigated.Methods: Hot water extracts (HWE) of SGT were used for the studies. In passive avoidance performances (step through test), active avoidance performances (lever press test), Motor activity, pentobarbital-induced sleep, 20 and 50 ㎎/100 g of SGT-HWE ameliorated the memory retrieval deficit induced by 40% ethanol. Results: The SGT-HWE did not affect the ambulatory activity of normal mice in normal condition. 20 and 50 ㎎/100 g of SGT-HWE enhanced contextual fear memory, but not cued fear memory in a fear conditioning task, which requires the activation of the NMDA (N-methyl-D-aspartase) receptor. SGT-HWE did not affect the motor activity measured by the titling type ambulometer test performed immediately and 24 hr after the administration. SGT-HWE prolonged the sleeping time induced by 50 mg/kg pentobarbital in mice and decreased SMA (spontaneous motor activity) in active avoidance performances (lever press test). Conclusion: These results indicate that the SGT-HWE have an improving effect on the memory retrieval disability induced by ethanol and may act as a stimulating factor for activating the NMDA receptor. and the SGT-HWE has a tranquilizing and anti-anxiety action.
- keywords
- Saenggitang, Learning and Memory Ability, Saenggitang, Learning and Memory Ability
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