- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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The Anti-nociceptive and Anti-inflammatory Effect of Achyranthes Japonica Nakai
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2004, v.25 no.4, pp.8-14
Hi-Joon,
P.
, Ji-Suk,
L.
, Mi-Sook,
H.
, Jin-Woo,
K.
, &
Sabina,
L.
(2004). The Anti-nociceptive and Anti-inflammatory Effect of Achyranthes Japonica Nakai. Journal of Korean Medicine, 25(4), 8-14.
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Abstract
Objectives : Achyranthes japonica Nakai (AJ) has been classified as a herb that activates blood flow and clears the stagnated blood. In this study, we evaluated its anti-nociceptive and anti-inflammatory activity in animals to clarify the effect of AJ on pain or inflammation. Methods : ICR mice and Sprague-Dawley rats were pretreated with an ethanolic extract of AJ with two dosages of 200 mg/kg (p.o.) and 400 mg/kg (p.o.). Nociceptive responses of acute pain were determined by hotplate and tail-flick tests. The effects of AJ on inflammation were evaluated by flexion/extention test and mechanical hyperalgesia test in models induced by both carrageenan and Complete Freund's Adjuvant (CFA). Results : AJ showed significant analgesic effects in both hotplate and tail-flick tests at the dose of 400 mg/kg. It also produced a significant inhibition of carrageenan-induced paw edema and CFA induced arthritis in rats at the dose of 400 mg/kg. Conclusion : We have demonstrated the analgesic and anti-inflammatory properties of an 80% ethanolic extract of AJ in animals. This suggests the application of AJ in relief of pain or inflammatory disease.
- keywords
- Analgesia, Inflammation, Achyranthes japonica Nakai, Analgesia, Inflammation, Achyranthes japonica Nakai
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