• P-ISSN1010-0695
  • E-ISSN2288-3339

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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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The Anti-nociceptive and Anti-inflammatory Effect of Achyranthes Japonica Nakai

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2004, v.25 no.4, pp.8-14







Hi-Joon, P. , Ji-Suk, L. , Mi-Sook, H. , 김창주, Jin-Woo, K. , 이혜정, & Sabina, L. (2004). . , 25(4), 8-14.
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Abstract

Objectives : Achyranthes japonica Nakai (AJ) has been classified as a herb that activates blood flow and clears the stagnated blood. In this study, we evaluated its anti-nociceptive and anti-inflammatory activity in animals to clarify the effect of AJ on pain or inflammation. Methods : ICR mice and Sprague-Dawley rats were pretreated with an ethanolic extract of AJ with two dosages of 200 mg/kg (p.o.) and 400 mg/kg (p.o.). Nociceptive responses of acute pain were determined by hotplate and tail-flick tests. The effects of AJ on inflammation were evaluated by flexion/extention test and mechanical hyperalgesia test in models induced by both carrageenan and Complete Freund's Adjuvant (CFA). Results : AJ showed significant analgesic effects in both hotplate and tail-flick tests at the dose of 400 mg/kg. It also produced a significant inhibition of carrageenan-induced paw edema and CFA induced arthritis in rats at the dose of 400 mg/kg. Conclusion : We have demonstrated the analgesic and anti-inflammatory properties of an 80% ethanolic extract of AJ in animals. This suggests the application of AJ in relief of pain or inflammatory disease.

keywords
Analgesia, Inflammation, Achyranthes japonica Nakai, Analgesia, Inflammation, Achyranthes japonica Nakai


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