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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

Novel Therapeutic Approach toward Inflammatory Diseases: Targeting Transglutaminase 2

Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2004, v.25 no.4, pp.188-199
Soo-Youl Kim (Weill Medical College of Cornell University and Burke Medical Research Institute)
Hong-Yeoul Kim
Jae-Dong Lee
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Abstract

Transglutaminase 2 (TGase 2) is an enzyme that is widely used in many biological systems for generic tissue stabilization purposes or immediate defenses for wounds. Many reports have showed that TGase 2 is aberrantly activated in tissues and cells and contributes to a variety of diseases, including neurodegenerative diseases and autoimmune diseases. In most cases, the TGase 2 appears to be a factor in the formation of inappropriate proteinaceous aggregates that may be cytotoxic. However, in other cases such as celiac disease, arthritis, lupus, amyotrophic lateral sclerosis, TGase 2 is involved in the generation of autoantibodies. This suggests the possibility that the inappropriate expression and/or presentation of TGase 2 to T cells might contribute to these diseases in genetically predisposed individuals. Others and we have found that TGase 2 expression is also increased in the inflammation process. We also demonstrated reverse of inflammation by TGase inhibition. Furthermore we discovered the genuine role of TGase 2 in immune cell activation. Increase of TGase activity induces or exacerbates inflammation via NF-B activation without I-B kinase signalings. This review will examine a possibility of TGase inhibitors as therapeutic agents in a variety of inflammatory diseases.

keywords
Transglutaminase, transglutaminase inhibitor, inflammation, autoimmune disease, Transglutaminase, transglutaminase inhibitor, inflammation, autoimmune disease


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