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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

Study on the Relationship between Candidate Genes of Cerebral Infarction and Sasang Constitution

Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2004, v.25 no.4, pp.209-219
Hye-Sun park
Kyung-Yo Kim
Jong-Cheon Joo
Jong-Yeol Kim (Korea Institute of Oriental Medicine)
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Abstract

The author investigated whether ACE/DD, AGN/TT, and ApoE/ε4 genotypes are associated with CI and whether genetic risk is enhanced by Sasang constitutional classification. The author ascertained these genotypes in patients with CI (n=211), diagnosed by brain computed tomography. Control subjects for the infarction group were randomly selected from 319 subjects matched for age, gender, and history of hypertension with patients. The ACE/DD genotype was not associated with CI. However, there was significant association between ApoE polymorphism and CI (χ2=15.089, p<.05). Furthermore, frequency of AGN/TT genotype was higher in the patients with CI than in the controls (χ2=20.072, p<.05). The frequency of T allele was 0.91 in patients and 0.82 in controls (χ2=17.237, p<.05). However, the Sasang constitutional classification did not increase the relative risk for CI in the subjects with ApoE/4 or AGN/T allele. These results suggest that ApoE and AGN polymorphism predict CI, but Sasang constitutional classification does not enhance the risk for CI associated with ApoE/4 or AGN/TT in a Korean population.

keywords
Cerebral infarction, ACE polymorphism, Apo E polymorphism, AGN polymorphism, Sasang constitution, Korean population


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