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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

Inhibitory effects of transforming growth factor and Drynariae Rhizoma on leukocytosis associated with the chronic phase of arthritis in mice

Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2004, v.25 no.4, pp.26-35
Sung-Min Bae
Ji-Cheon Jeong
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Abstract

Drynariae Rhizoma (DR), an herbal medicine known to clean blood and improve its circulation, frequently appears as the main ingredient in the prescriptions for bone injuries. Currently, it is unclear how contributes pharmacologically to the reformation of bone. Therefore, we have done this study. Systematic administrations of TGFβ1 and water extract of DR diminished the polyarthritis development in rats. TGFβ administration (0.1-2 μg/animal) and DR (10-100 μg/animal), initiated 1 day before an arthritogenic dose of streptococcal cell wall fragments, virtually eliminated the joint swelling and distortion observed during the acute phase and the chronic phase of the disease. The TGFβ and DR synergistically suppressed the arthritis when the administration was begun after the acute phase of arthritis. Also, the synergistic activity between TGFβ and DR was confirmed in their suppression of arthritis in rats. Consistent with the inhibition of inflammatory cell recruitment into the synovium, TGFβ1 and DR reversed the leukocytosis associated with the chronic phase of the arthritis.

keywords
Drynariae Rhizoma, arthritis, leukocytosis, streptococcal cell wall (SCW)transforming growth factor (TGF), Drynariae Rhizoma, arthritis, leukocytosis, streptococcal cell wall (SCW)transforming growth factor (TGF)


Reference

1

(1991;63) Osteoporosis with Kampo treatment,

2

(1997) Medicinal Herbs, New World Press

3

(1987;106) Postmenopausal bone loss is prevented by treatment with low-dosage estrogen with calcium,

4

(2000) Effects of complex extracts containing Drynariae Rhizoma on suppression of collagenolysis and bone resorption in mouse calvarial osteoblasts,

5

(1991;6183-90) Role of prostaglandins in interleukin-1 induced bone resorption in mice in vitro,

6

(1992) Encyclopedia of esoteric prescriptions in traditional Chinese Medicine Surgery/Bone Injury vol, Holiday Press

7

(2001) Preventive effects of Drynariae Rhizoma on experimental bone disorder in rats,

8

(1996) Anti-CD4 monoclonal antibodies suppress murine collagen- induced arthritis only at the time of primary immunisation,

9

(1996) Transfer of type II collagen-induced arthritis from DBA/1 to severe combined immunodeficiency mice can be prevented by blockade of Mac-1,

10

(1986;83) BSC-1 growth inhibitor type β-TGF is a strong inhibitor of thymocyte proliferation,

11

(1991;87) TGFβ1 suppress acute and chronic arthritis in experimental animals,

12

(1997) Arthritis in rats after systematic injection of streptococcal cells or cell walls,

13

(1986;76) Role of the thymus in streptococcal cell wall-induced arthritis and hepatic granuloma formation,

14

(1990;406-11) a Practical English-Chinese Library of Traditional Chinese Medicine Publishing House of Shanghai Collage of Traditional Chinese Medicine,

15

(1999) Establishing an immortalized human osteoprecursor cell line: OPC1,

16

(1964;115) The role of endotoxin in the extracellular coagulation of limulus blood,

17

(1988;168) Role of TGFβ, Bacterial cell wall-induced immunosuppression

18

(1999) Rehmannia Glutinosa inhibits tumor necrosis factor-alpha and interleukin-1 secretion from mouse astrocytes,

19

(1987;262) Latent TGFβ in serum,

20

(1989;1) Bacterial cell wall induced chronic inflammation is associated with increased CSF production and leukocytosis,

21

(1989;143) Inhibition of early murine hematopietic precursor cell proliferation after in vivo locoregional administration of TGFβ1,

22

(1988;140) Regulation of colony stimulating actor 1-dependent macrophage precursor proliferation by type TGFβ,

23

(1988;39) possible role in the regulation of normal and leukemic hematopoietic growth,

24

(1988;242) Endothelial adhesiveness for blood neutrophils is inhibited by TGFβ,

25

(1990;172) TGFβ os a potent inhibitor of interleukin 1 proposed mechanism of inhibition of IL-1 action,

26

(1988;334) Deactivation of macrophages by TGFβ,

27

(1990;249) Mediation of cardioprotection by TGFβ,

28

(1988;157) TGFβ is a potenr inhibitor of IL-1 induced chondrocyte protease acticity and cartilage proteoglycan degradation,

29

(1988;85) Infusions of recombinant human interleukin 1α and 1β cause hypercalcemia in normal mice,

30

(1995) Use of an in vivo model to determine the effects of interleukin-1 on cells at different stages in the osteoclast lineage,

31

(1988;85) TGFβ inhibits formation of osteoclast-like cells in long term human marrow culture,

32

(1988;82) TGFβ inhibits bone resorption in fetal rat long bone cultures,

33

(1989;10) Inflamamtory and immunomodulatory roles of TGFβ,

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