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- E-ISSN 2288-8985
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Trace Analysis of Racemic Isomers of Flurbiprofen in Human Urine using Column Switching-HPLC
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2002, v.15 no.6, pp.529-533
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(2002). Trace Analysis of Racemic Isomers of Flurbiprofen in Human Urine using Column Switching-HPLC. Analytical Science and Technology, 15(6), 529-533.
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Abstract
The separation and determination method of racemic isomers of flurbiprofen in urine samples have been investigated using column switching- HPLC, which include the sample treatment and concentration column. The optical rotation of two isomers separated were measured to identify d-form and l-form. The calibration curves are liear in the ranges of <TEX>$0.11-5.4{\mu}g/mL$</TEX> for both d-form and l-form. The detection limits were <TEX>$0.031{\mu}g/mL$</TEX> for l-isomes and <TEX>$0.027{\mu}g/mL$</TEX> for d-isomer. The coefficients of variation of intra-day and inter-day precision of this method were about 1.8%. The present method was apllied to determine the concentration of racemic isomers in urine sample from human eating the drug.
- keywords
- Column - Switching HPLC, Racemic compound, Flurbiprofen, Specific rotation
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